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Curriculum Vitae

  • Date: 2023-01-16
  • Update: 2023-01-16
  • Source: NHRI
  • Views: 3189
Vice President Wayne Huey-Herng Sheu M.D., MS, PhD

Vice President
Wayne Huey-Herng Sheu M.D., MS, PhD

E-mail：whhsheu@nhri.edu.tw

Education

1976.09-1983.09, School of Medicine, National Defense Medical Center (NDMC), Taipei, Taiwan (MD)
1985.09-1989.05, Institute of Medical Sciences, NDMC, Taipei, Taiwan (PhD)
2001.09-2003.06, Graduate Institute of Health Care Organization, National Taiwan University, Taipei, Taiwan (MS)

Publication list (*indicated corresponding author)

  1. Shen DC, Davidson MB, Kuo SW, Sheu WH. Peripheral and hepatic insulin antagonism in hyperthyroidism. J Clin Endocrinol Metab. 1988 Mar;66(3):565-9.
  2. Swislocki AL, Hoffman BB, Sheu WH, Chen YD, Reaven GM. Effect of prazosin treatment on carbohydrate and lipoprotein metabolism in patients with hypertension. Am J Med. 1989 Jan 23;86(1B):14-8.
  3. Wu MS, Johnston P, Sheu WH, Goldfine ID, Chen YD, Reaven GM. Effect of metformin on carbohydrate and lipoprotein metabolism in NIDDM patients. Diabetes Care. 1990 Jan;13(1):1-8.
  4. Sheu WH, Hollenbeck CB, Wu MS, Jaspan JB, Chen YD, Reaven GM. Effect of difference in glucose infusion rate on quantification of hepatic glucose production. J Clin Endocrinol Metab. 1990 May;70(5):1354-60.
  5. Fuh MM, Sheu WH, Shen DC, Wu DA, Chen YD, Reaven GM. Metabolic effects of diuretic and beta-blocker treatment of hypertension in patients with non-insulin-dependent diabetes mellitus. Am J Hypertens. 1990 May;3(5 Pt 1):387-90.
  6. Sheu WH, Swislocki AL, Hoffman BB, Reaven GM, Chen YD. Effect of prazosin treatment on HDL kinetics in patients with hypertension. Am J Hypertens. 1990 Oct;3(10):761-8.
  7. Chen YD, Sheu WH, Swislocki AL, Reaven GM. High density lipoprotein turnover in patients with hypertension. Hypertension. 1991 Mar;17(3):386-93.
  8. Sheu WH, Swislocki AL, Hoffman B, Chen YD, Reaven GM. Comparison of the effects of atenolol and nifedipine on glucose, insulin, and lipid metabolism in patients with hypertension. Am J Hypertens. 1991 Mar;4(3 Pt 1):199-205.
  9. Sheu WH, Jeng CY, Shieh SM, Shen DD, Chen YD, Reaven GM. Insulin resistance and abnormal electrocardiograms in patients with high blood pressure. Am J Hypertens. 1992 Jul;5(7):444-8.
  10. Shieh SM, Sheu WH, Shen DD, Jeng JR, Chen YD, Reaven GM. Improvement in metabolic risk factors for coronary heart disease associated with cilazapril treatment. Am J Hypertens. 1992 Aug;5(8):506-10.
  11. Sheu WH, Hou JC, Jeng CY, Fuh MM. Reproducibility of the measurement of insulin sensitivity by the modified insulin suppression test. J Formos Med Assoc. 1992 Sep;91(9):859-63.
  12. Shieh SM, Sheu WH, Shen DC, Fuh MM, Chen YD, Reaven GM. Glucose, insulin, and lipid metabolism in doxazosin-treated patients with hypertension. Am J Hypertens. 1992 Nov;5(11):827-31.
  13. Reaven GM, Chen YD, Hollenbeck CB, Sheu WH, Ostrega D, Polonsky KS. Plasma insulin, C-peptide, and proinsulin concentrations in obese and nonobese individuals with varying degrees of glucose tolerance. J Clin Endocrinol Metab. 1993 Jan;76(1):44-8.
  14. Sheu WH, Shieh SM, Fuh MM, Jeng CY, Chen YD, Reaven GM. Insulin resistance, glucose intolerance, and hyperinsulinemia. Hypertriglyceridemia versus hypercholesterolemia. Arterioscler Thromb. 1993 Mar;13(3):367-70.
  15. Wang DJ, Shen DC, Sheu WH, Chu NF, Fuh MM, Chen LM. Effect of nicardipine treatment on carbohydrate and lipoprotein metabolism in patients with hypertension. Clin Exp Hypertens. 1993 May;15(3):557-73.
  16. Jeng CY, Sheu WH, Jaspan JB, Polonsky KS, Chen YD, Reaven GM. Glucagon does not increase plasma free fatty acid and glycerol concentrations in patients with noninsulin-dependent diabetes mellitus. J Clin Endocrinol Metab. 1993 Jul;77(1):6-10.
  17. Young MH, Jeng CY, Sheu WH, Fuh MM, Chen YD, Reaven GM. Insulin resistance, glucose intolerance, hyperinsulinemia and dyslipidemia in patients with angiographically demonstrated coronary artery disease. Am J Cardiol. 1993 Aug 15;72(5):458-60.
  18. Fuh MM, Jeng CY, Young MM, Sheu WH, Chen YD, Reaven GM. Insulin resistance, glucose intolerance, and hyperinsulinemia in patients with microvascular angina. Metabolism. 1993 Sep;42(9):1090-2.
  19. Sheu WH, Hsu CH, Chen YS, Jeng CY, Fuh MM. Prospective evaluation of insulin resistance and lipid metabolism in women receiving oral contraceptives. Clin Endocrinol (Oxf). 1994 Feb;40(2):249-55.
  20. Sheu WH, Shieh SM, Shen DD, Jeng CY, Chen YD, Reaven GM. Effect of pravastatin treatment on glucose, insulin, and lipoprotein metabolism in patients with hypercholesterolemia. Am Heart J. 1994 Feb;127(2):331-6.
  21. Lu KC, Shieh SD, Lin SH, Li BL, Sheu WH, Ding YA. Hyperparathyroidism, glucose tolerance and platelet intracellular free calcium in chronic renal failure. Q J Med. 1994 Jun;87(6):359-65.
  22. Sheu WH, Jeng CY, Shieh SM, Fuh MM. Hepatic insulin extraction and insulin clearance in patients with essential hypertension. Clin Exp Hypertens. 1994 Sep;16(5):691-707.
  23. Jeng CY, Sheu WH, Fuh MM, Chen YD, Reaven GM. Relationship between hepatic glucose production and fasting plasma glucose concentration in patients with NIDDM. Diabetes. 1994 Dec;43(12):1440-4.
  24. Maheux P, Jeppesen J, Sheu WH, Greenfield MS, Chen YD, Reaven GM. Additive effects of obesity, hypertension, and type 2 diabetes on insulin resistance. Hypertension. 1994 Dec;24(6):695-8.
  25. Fuh MM, Yin CS, Pei D, Sheu WH, Jeng CY, Chen YI, Reaven GM. Resistance to insulin-mediated glucose uptake and hyperinsulinemia in women who had preeclampsia during pregnancy. Am J Hypertens. 1995 Jul;8(7):768-71.
  26. Sheu WH, Wei J, Jeng CY, Fuh MM, Chen YD. Metabolic abnormalities following heart transplantation in patients with idiopathic cardiomyopathy. Horm Metab Res. 1995 Oct;27(10):469-72.
  27. Su HY, Sheu WH, Chin HM, Jeng CY, Chen YD, Reaven GM. Effect of weight loss on blood pressure and insulin resistance in normotensive and hypertensive obese individuals. Am J Hypertens. 1995 Nov;8(11):1067-71.
  28. Sheu WH, Jeng CY, Fuh MM, Chen YD, Reaven GM. Effect of glipizide treatment on response to an infused glucose load in patients with NIDDM. Diabetes Care. 1995 Dec;18(12):1582-7.
  29. Sheu WH, Jeng CY, Shieh SM, Fuh MM. Suppression of non-esterified fatty acid concentrations by insulin in patients with hypertension. Zhonghua Yi Xue Za Zhi (Taipei). 1995 Dec;56(6):367-72.
  30. Wu DA, Bu X, Warden CH, Sheu WH, Rotter JI, Chen YD. Quantitative trait locus mapping of human blood pressure to a genetic region at or near the lipoprotein lipase gene locus on chromosome 8p22. J Clin Invest. 1996 May 1;97(9):2111-8.
  31. Jeng JR, Sheu WH, Jeng CY, Huang SH, Shieh SM. Impaired fibrinolysis and insulin resistance in patients with hypertension. Am J Hypertens. 1996 May;9(5):484-90.
  32. Jeng CY, Sheu WH, Fuh MM, Shieh SM, Chen YD, Reaven GM. Gemfibrozil treatment of endogenous hypertriglyceridemia: effect on insulin-mediated glucose disposal and plasma insulin concentrations. J Clin Endocrinol Metab. 1996 Jul;81(7):2550-3.
  33. Jeng JR, Sheu WH, Jeng CY, Huang SH, Shieh SM. Effect of doxazosin on fibrinolysis in hypertensive patients with and without insulin resistance. Am Heart J. 1996 Oct;132(4):783-9.
  34. Bau CT, Sheu WH*, Song YM, Tseng LN, Wang CC. Acanthosis nigricans and diabetic ketoacidosis. Diabetes Care. 1997 Jul;20(7):1202.
  35. Jeng JR, Shieh SM, Harn HJ, Lee MM, Sheu WH, Jeng CY. Angiotensin I converting enzyme gene polymorphism and insulin resistance in patients with hypertension. J Hypertens. 1997 Sep;15(9):963-8.
  36. Jeng JR, Jeng CY, Sheu WH, Lee MM, Huang SH, Shieh SM. Gemfibrozil treatment of hypertriglyceridemia: improvement on fibrinolysis without change of insulin resistance. Am Heart J. 1997 Sep;134(3):565-71.
  37. Chen MD, Lin PY, Sheu WH. Zinc status in plasma of obese individuals during glucose administration. Biol Trace Elem Res. 1997 Oct-Nov;60(1-2):123-9.
  38. Sheu WH, Lee WJ. Abnormal gonadotropin release and carbohydrate metabolism in morbid obese women. Chin J Physiol. 1997 Dec 31;40(4):207-12.
  39. Sheu WH*, Chin HM, Su HY, Jeng CY. Effect of weight loss on resting energy expenditure in hypertensive and normotensive obese women. Clin Exp Hypertens. 1998 May;20(4):403-16.
  40. Sheu WH*, Lee WJ, Jeng CY, Young MS, Ding YA, Chen YT. Angiotensinogen gene polymorphism is associated with insulin resistance in nondiabetic men with or without coronary heart disease. Am Heart J. 1998 Jul;136(1):125-31.
  41. Pei D, Sheu WH, Jeng CY, Liao WK, Fuh MM. Insulin resistance in patients with Klinefelter's syndrome and idiopathic gonadotropin deficiency. J Formos Med Assoc. 1998 Aug;97(8):534-40.
  42. Wu CJ, Sheu WH. Type 2 diabetes in adults with pseudopseudohypoparathyroidism. Case report. Diabetes Care. 1998 Sep;21(9):1575-6.
  43. Wu CJ, Chen HL, Song YM, Sheu WH, Chen SH. Mixed medullary-follicular carcinoma and papillary carcinoma of the same thyroid. Intern Med. 1998 Nov;37(11):955-7.
  44. Lee WJ, Sheu WH, Shu SG, Yao YE. Genetic analysis of the insulin receptor gene in Chinese patients with extreme insulin resistance. Zhonghua Yi Xue Za Zhi (Taipei). 1998 Nov;61(11):636-42.
  45. Hsu CW, Ho CL, Sheu WH, Harn HJ, Chao TY. Adrenal insufficiency caused by primary aggressive non-Hodgkin's lymphoma of bilateral adrenal glands: report of a case and literature review. Ann Hematol. 1999 Mar;78(3):151-4.
  46. Sheu WH, Song YM, Lee WJ, Tseng LN, Bau CT, Bai CL. Family aggregation and maternal inheritance of Chinese type 2 diabetes mellitus in Taiwan. Zhonghua Yi Xue Za Zhi (Taipei). 1999 Mar;62(3):146-51.
  47. Song YM, Sheu WH, Lee WJ, Wu CJ, Kao CH. Plasma leptin concentrations are related to body fat mass and gender but not to thyroid dysfunction. Kaohsiung J Med Sci. 1999 Mar;15(3):119-26.
  48. Sheu WH*, Lee WJ, Yao YE, Jeng CY, Young MM, Chen YT. Lack of association between genetic variation in the beta3-adrenergic receptor gene and insulin resistance in patients with coronary heart disease. Metabolism. 1999 May;48(5):651-4.
  49. Sheu WH*, Juang BL, Chen YT, Lee WJ. Endothelial dysfunction is not reversed by simvastatin treatment in type 2 diabetic patients with hypercholesterolemia. Diabetes Care. 1999 Jul;22(7):1224-5.
  50. Sheu WH*, Lee WJ, Chen YT. Gender differences in relation to leptin concentration and insulin sensitivity in nondiabetic Chinese subjects. Int J Obes Relat Metab Disord. 1999 Jul;23(7):754-9.
  51. Chen MD, Lin PY, Sheu WH. Zinc coadministration attenuates melatonin's effect on nitric oxide production in mice. Biol Trace Elem Res. 1999 Sep;69(3):261-8.
  52. Sheu WH*, Lee WJ, Chen YT. High plasma leptin concentrations in hypertensive men but not in hypertensive women. J Hypertens. 1999 Sep;17(9):1289-95.
  53. Wu CJ, Song YM, Sheu WH. Short stature in a 46,XX male adolescent. South Med J. 1999 Sep;92(9):921-3.
  54. Lin SY, Sheu WH*, Lee WJ, Song YM, Chen YT. Trp64Arg polymorphism of the beta 3-adrenergic receptor gene is associated with increased plasma leptin levels in obese Chinese women. Zhonghua Yi Xue Za Zhi (Taipei). 1999 Sep;62(9):569-76.
  55. Yan SH, Sheu WH*, Song YM, Tseng LN. The occurrence of diabetic ketoacidosis in adults. Intern Med. 2000 Jan;39(1):10-4.
  56. Sheu WH*, Lee WJ, Chen YT. Plasma homocysteine concentrations and insulin sensitivity in hypertensive subjects. Am J Hypertens. 2000 Jan;13(1 Pt 1):14-20.
  57. Sheu WH*, Jeng CY, Young MS, Le WJ, Chen YT. Coronary artery disease risk predicted by insulin resistance, plasma lipids, and hypertension in people without diabetes. Am J Med Sci. 2000 Feb;319(2):84-8.
  58. Song YM, Chen MD, Sheu WH. Effect of acarbose administration on plasma concentrations of zinc and copper in patients with NIDDM. Kaohsiung J Med Sci. 2000 Apr;16(4):187-91.
  59. Song YM, Sheu WH. Pituitary tumor cosecreting thyrotropin and prolactin causing hyperthyroidism--a case report. Kaohsiung J Med Sci. 2000 Apr;16(4):203-9.
  60. Wu CJ, Song YM, Sheu WH. Tertiary hyperparathyroidism in X-linked hypophosphatemic rickets. Intern Med. 2000 Jun;39(6):468-71.
  61. Lee WJ, Sheu WH, Jeng CY, Young MS, Chen YT. Associations between lipoprotein lipase gene polymorphisms and insulin resistance in coronary heart disease. Zhonghua Yi Xue Za Zhi (Taipei). 2000 Jul;63(7):563-72.
  62. Song YM, Lee WJ, Chen MD, Kao CH, Sheu WH. Methylprednisolone increases plasma leptin levels in Graves' hyperthyroidism patients with active Graves' ophthalmopathy. Horm Metab Res. 2000 Jul;32(7):277-82.
  63. Chen MD, Song YM, Tsou CT, Lin WH, Sheu WH. Leptin concentration and the Zn/Cu ratio in plasma in women with thyroid disorder. Biol Trace Elem Res. 2000 Summer;75(1-3):99-105.
  64. Wu CJ, Song YM, Sheu WH. [Tertiary hyperparathyroidism in X-linked hypophosphatemic rickets] [In Process Citation]. Nihon Naika Gakkai Zasshi. 2000 Jul 10;89(7):1349-57.
  65. Chen MD, Song YM, Tsou CT, Lin WH, Sheu WH. Plasma concentrations of leptin and selected minerals do not differ in Type 2 diabetic patients with or without sulfonylurea inefficacy. Diabetes Nutr Metab. 2000 Oct;13(5):284-6.
  66. Tai TS, Sheu WH*, Lee WJ, Yao HT, Chiang MT. Effect of chitosan on plasma lipoprotein concentrations in type 2 diabetic subjects with hypercholesterolemia. Diabetes Care. 2000 Nov;23(11):1703-4.
  67. Sheu WH*, Jeng CY, Lee WJ, Lin SY, Pei D, Chen YT. Simvastatin treatment on postprandial hypertriglyceridemia in type 2 diabetes mellitus patients with combined hyperlipidemia. Metabolism. 2001 Mar;50(3):355-9.
  68. Yu HI, Sheu WH*, Lai CJ, Lee WJ, Chen YT. Endothelial dysfunction in type 2 diabetes mellitus subjects with peripheral artery disease. Int J Cardiol. 2001 Mar;78(1):19-25.
  69. Song YM, Sheu WH, Lee WJ. Acute biochemical variations induced by calcium citrate and calcium carbonate in Type 2 diabetic patients: impaired calcium absorption in Type 2 diabetic patients with prolonged gastric emptying time. J Diabetes Complications. 2001 Mar-Apr;15(2):97-102.
  70. Chen MD, Sheu WH. Plasma status of selected minerals in hypertensive men with and without insulin resistance. J Trace Elem Med Biol. 2001 Apr;14(4):228-31.
  71. Sheu WH*, Wu HS, Wang CW, Wan CJ, Lee WJ. Elevated plasma homocysteine concentrations six months after gastroplasty in morbidly obese subjects. Intern Med. 2001 Jul;40(7):584-8.
  72. Sheu WH*, Chen YT, Lee WJ. Improvement in endothelial dysfunction with LDL cholesterol level < 80 mg/dl in type 2 diabetic patients. Diabetes Care. 2001 Aug;24(8):1499-501.
  73. Chao CS, Sheu WH*. Free fatty acids and hyperglycemia on the vascular wall: what do we learn?. Zhonghua Yi Xue Za Zhi (Taipei). 2001 Aug;64(8):433-4.
  74. Chuang LM, Hsiung CA, Sheu WH, Pratt RE, Lei HH, Tai TY. Sibling-based association study of the PPARgamma2 Pro12Ala polymorphism and metabolic variables in Chinese and Japanese hypertension families: a SAPPHIRe study. Stanford Asian-Pacific Program in Hypertension and Insulin Resistance. J Mol Med (Berl). 2001 Nov;79(11):656-64.
  75. Sheu WH*, Lee WJ, Lin LY, Chang RL, Chen YT. Tumor necrosis factor alpha -238 and -308 polymorphisms do not associate with insulin resistance in hypertensive subjects. Metabolism. 2001 Dec;50(12):1447-51.
  76. Chao CS, Lin SY, Sheu WH. Graves' disease presented as painful goiter. Horm Res. 2002;57(1-2):53-6.
  77. Lee IT, Lin SY, Sheu WH. Serial body composition by bioimpedance analysis in a diabetic subject with rapid insulin-induced weight gain--a case report. Kaohsiung J Med Sci. 2002 Jan;18(1):45-8.
  78. Lin SY, Sheu WH, Chang MC, Tang KT, Lee TI, Lin HD. Diagnosis of thyroid metastasis in cancer patients with thyroid mass by fine needle aspiration cytology and ultrasonography. Zhonghua Yi Xue Za Zhi (Taipei). 2002 Mar;65(3):101-5.
  79. Ranade K, Jorgenson E, Sheu WH, Cox DR, Botstein D, Risch N. A polymorphism in the beta1 adrenergic receptor is associated with resting heart rate. Am J Hum Genet. 2002 Apr;70(4):935-42.
  80. Chao CS, Lin SY, Sheu WH, Ho WL. Thyroglossal duct cyst with papillary carcinoma. Zhonghua Yi Xue Za Zhi (Taipei). 2002 Apr;65(4):183-6.
  81. Wu KD, Hsiao CF, Sheu WH, Dzau VJ, Cox D, Tai TY. Clustering and heritability of insulin resistance in Chinese and Japanese hypertensive families: a Stanford-Asian Pacific Program in Hypertension and Insulin Resistance sibling study. Hypertens Res. 2002 Jul;25(4):529-36.
  82. Hsu HY, Chen YT, Sheu WH, Sheng WY, Chao AC. Comparison of brachial artery flow-mediated vasodilatation in symptomatic and asymptomatic patients with carotid arterial stenosis. Am J Cardiol. 2002 Oct 1;90(7):814-6.
  83. Lee IT, Sheu WH*, Lin SY, Lee WJ, Song YM, Liu HC. Simvastatin reduces plasma concentration of high-sensitivity C-reactive protein in type 2 diabetic patients with hyperlipidemia. J Diabetes Complications. 2002 Nov-Dec;16(6):382-5.
  84. Lee IT, Sheu WH, Lin SY. Hypoglycemia probably due to accidental intake of repaglinide. Chang Gung Med J. 2002 Nov;25(11):783-6.
  85. Lin SY, Wang YY, Sheu WH. Increased serum leptin concentrations correlate with soluble tumour necrosis factor receptor levels in patients with cirrhosis. Clin Endocrinol (Oxf). 2002 Dec;57(6):805-11.
  86. Lee IT, Sheu WH, Lin SY. Familial form of thyroid dysgenesis: report of thyroid hemiagenesis with accompanying Graves' disease in a woman whose daughter has thyroid agenesis. Horm Res. 2003;59(1):47-9.
  87. Lee IT, Sheu WH*, Liau YJ, Lin SY, Lee WJ, Lin CC. Relationship of stressful life events, anxiety and depression to hyperthyroidism in an asian population. Horm Res. 2003;60(5):247-51.
  88. Tai TS, Lin SY, Sheu WH. Metabolic effects of growth hormone therapy in an Alstrom syndrome patient. Horm Res. 2003;60(6):297-301.
  89. Chen HL, Sheu WH, Tai TS, Liaw YP, Chen YC. Konjac supplement alleviated hypercholesterolemia and hyperglycemia in type 2 diabetic subjects-a randomized double-blind trial. J Am Coll Nutr. 2003 Feb;22(1):36-42.
  90. Sheu WH*, Chen YT, Lee WJ, Wang CW, Lin LY. A relationship between serum ferritin and the insulin resistance syndrome is present in non-diabetic women but not in non-diabetic men. Clin Endocrinol (Oxf). 2003 Mar;58(3):380-5.
  91. Hwu CM, Hsiao CF, Sheu WH, Pratt R, Chen YD, Ho LT. Sagittal abdominal diameter is associated with insulin sensitivity in Chinese hypertensive patients and their siblings. J Hum Hypertens. 2003 Mar;17(3):193-8.
  92. Lin SY, Wang YY, Sheu WH. Preoperative plasma concentrations of vascular endothelial growth factor and matrix metalloproteinase 9 are associated with stage progression in papillary thyroid cancer. Clin Endocrinol (Oxf). 2003 Apr;58(4):513-8.
  93. Yu HI, Sheu WH, Song YM, Liu HC, Lee WJ, Chen YT. C-reactive protein and risk factors for peripheral vascular disease in subjects with Type 2 diabetes mellitus. Diabet Med. 2004 Apr;21(4):336-41.
  94. Lin RT, Lee WJ, Jeng CY, Sheu WH, Chen YT. Metabolic syndrome and its contribution to coronary artery disease in non-diabetic subjects. J Formos Med Assoc. 2004 Apr;103(4):317-20.
  95. Lin SY, Wang YY, Sheu WH. Increased serum soluble tumor necrosis factor receptor levels are associated with insulin resistance in liver cirrhosis. Metabolism. 2004 Jul;53(7):922-6.
  96. Lu TM, Ding YA, Leu HB, Yin WH, Sheu WH, Chu KM. Effect of rosuvastatin on plasma levels of asymmetric dimethylarginine in patients with hypercholesterolemia. Am J Cardiol. 2004 Jul 15;94(2):157-61.
  97. Lee WL, Sheu WH, Liu TJ, Liao MF, Chen YT, Ting CT. The short-/intermediate-term changes in novel vascular inflammatory markers after angioplasty plus stenting in patients with symptomatic advanced systemic arterial diseases. Atherosclerosis. 2004 Sep;176(1):125-32.
  98. Sheu WH*, Lee WJ, Chen YT. Combined use of fasting glucose and hemoglobin a levels in screening for new type 2 diabetes mellitus in elderly men: TCVGHAGE. J Am Geriatr Soc. 2004 Oct;52(10):1777-8.
  99. Chuang LM, Chiu YF, Sheu WH, Chen YD, Hsiung CA, Tai TY. Biethnic comparisons of autosomal genomic scan for loci linked to plasma adiponectin in populations of Chinese and Japanese origin. J Clin Endocrinol Metab. 2004 Nov;89(11):5772-8.
  100. Sheu WH. The metabolic syndrome: what have we learned? J Chin Med Assoc. 2004 Dec;67(12):597-9.
  101. Hung YJ, Hsieh CH, Pei D, Lee CH, Fan SC, Sheu WH. Rosiglitazone improves insulin sensitivity and glucose tolerance in subjects with impaired glucose tolerance. Clin Endocrinol (Oxf). 2005 Jan;62(1):85-91.
  102. Hsu HY, Wang PY, Chen YT, Sheu WH, Hu HH, Sheng WY. Changes in flow-mediated dilatation, cytokines and carotid arterial stenosis during aggressive atorvastatin treatment in normocholesterolemic patients. J Chin Med Assoc. 2005 Feb;68(2):53-8.
  103. Tseng ST, Sheu WH, Lee WJ, Ting CT, Chen YT, Jeng CY. Relationship between several surrogate estimates of insulin sensitivity in non-diabetic patients with coronary artery disease. J Formos Med Assoc. 2005 Feb;104(2):94-100.
  104. Lin SY, Chen WY, Lee FY, Huang CJ, Sheu WH*. Activation of ubiquitin-proteasome pathway is involved in skeletal muscle wasting in a rat model with biliary cirrhosis: potential role of TNF-alpha. Am J Physiol Endocrinol Metab. 2005 Mar;288(3):E493-501.
  105. Sheu WH*, Chin HM, Lee WJ, Wan CJ, Su HY, Lang HF. Prospective evaluation of folic acid supplementation on plasma homocysteine concentrations during weight reduction: a randomized, double-blinded, placebo-controlled study in obese women. Life Sci. 2005 Mar 18;76(18):2137-45.
  106. Lin SY, Sheu WH, Chen WY, Lee FY, Huang CJ. Stimulated resistin expression in white adipose of rats with bile duct ligation-induced liver cirrhosis: relationship to cirrhotic hyperinsulinemia and increased tumor necrosis factor-alpha. Mol Cell Endocrinol. 2005 Mar 31;232(1-2):1-8.
  107. Lin SY, Chen WY, Chiu YT, Lee WJ, Wu HS, Sheu WH*. Different tumor necrosis factor-alpha-associated leptin expression in rats with dimethylnitrosamine and bile duct ligation-induced liver cirrhosis. Metabolism. 2005 Apr;54(4):445-52.
  108. Hung YJ, Chen YC, Pei D, Lee CH, Fan SC, Sheu WH. Sibutramine improves insulin sensitivity without alteration of serum adiponectin in obese subjects with Type 2 diabetes. Diabet Med. 2005 Aug;22(8):1024-30.
  109. Wang YY, Lin SY, Lai WA, Liu PH, Sheu WH. Association between adenomas of rectosigmoid colon and metabolic syndrome features in a Chinese population. J Gastroenterol Hepatol. 2005 Sep;20(9):1410-5.
  110. Wang JS, Chen YW, Chow SE, Ou HC, Sheu WH. Exercise paradoxically modulates oxidized low density lipoprotein-induced adhesion molecules expression and trans-endothelial migration of monocyte in men. Thromb Haemost. 2005 Oct;94(4):846-52.
  111. Lee IT, Lin TM, Lee WJ, Tang YJ, Yang CH, Sheu WH*. Hypercholesterolemia, not metabolic syndrome, related to adhesion of monocytes to cultured endothelium in nondiabetic subjects. Metabolism. 2005 Nov;54(11):1467-71.
  112. Lin SY, Wang YY, Liu PH, Lai WA, Sheu WH. Lower serum free thyroxine levels are associated with metabolic syndrome in a Chinese population. Metabolism. 2005 Nov;54(11):1524-8.
  113. Chiou JB, Lin SY, Yen CH, Sheu WH, Jeng CY. Efficacy and safety of a mixture of two different brands of insulin products in patients with type 1 diabetes mellitus. J Chin Med Assoc. 2005 Nov;68(11):517-21.
  114. Pei D, Kuo SW, Wu DA, Chen SP, Sheu WH, Li JC. The relationships between insulin resistance and components of metabolic syndrome in Taiwanese Asians. Int J Clin Pract. 2005 Dec;59(12):1408-16.
  115. Lee WJ, Sheu WH, Chen YT, Liu TJ, Liang KW, Ting CT, Lee WL. Circulating CD40 ligand is elevated only in patients with more advanced symptomatic peripheral arterial diseases. Thromb Res. 2006;118(5):619-26.
  116. Lee IT, Sheu WH*, Tu ST, Kuo SW, Pei D.Bisphosphonate pretreatment attenuates hungry bone syndrome postoperatively in subjects with primary hyperparathyroidism.J Bone Miner Metab. 2006;24(3):255-8.
  117. Sheu WH*, Ou HC, Chou FP, Lin TM, Yang CH. Rosiglitazone inhibits endothelial proliferation and angiogenesis. Life Sci. 2006 Feb 23;78(13):1520-8.
  118. Sheu WH, Tseng YH. Uric acid: an additional component of metabolic syndrome?. J Chin Med Assoc. 2006 Mar;69(3):99-100.
  119. Hung YJ, Lin SH, Pei D, Hsing Lee C, Fan SC, Sheu WH. Rosiglitazone improves insulin sensitivity in nonobese subjects with impaired glucose tolerance: the role of adiponectin and C-reactive protein. Metabolism. 2006 Apr;55(4):439-44.
  120. Ou HC, Chou FP, Lin TM, Yang CH, Sheu WH*. Protective effects of honokiol against oxidized LDL-induced cytotoxicity and adhesion molecule expression in endothelial cells. Chem Biol Interact. 2006 May 15;161(1):1-13.
  121. Tseng LN, Sheu WH*, Ho ES, Lan HH, Hu CC, Kao CH. Effects of alendronate combined with hormone replacement therapy on osteoporotic postmenopausal Chinese women. Metabolism. 2006 Jun;55(6):741-7.
  122. Liang KW, Sheu WH, Lee WL, Ting CT, Chen YT, Lee WJ. Coronary artery disease progression is associated with C-reactive protein and conventional risk factors but not soluble CD40 ligand. Can J Cardiol. 2006 Jun;22(8):691-6.
  123. Lin SY, Sheu WH*. An emerging link between insulin resistance and inflammation. J Chin Med Assoc. 2006 Jun;69(6):245-7.
  124. Ou HC, Chou FP, Lin TM, Yang CH, Sheu WH*. Protective effects of eugenol against oxidized LDL-induced cytotoxicity and adhesion molecule expression in endothelial cells. Food Chem Toxicol. 2006 Sep;44(9):1485-95.
  125. Lin SD, Tu ST, Hsu SR, Lin KC, Sheu WH. Characteristics predicting dyslipidemia in drug-naïve type 2 diabetes patients. J Chin Med Assoc. 2006 Sep;69(9):404-8.
  126. Chen PL, Wang PY, Sheu WH, Ho YP, Hu HH, Hsu HY. Changes of brachial flow-mediated vasodilation in different ischemic stroke subtypes. Neurology. 2006 Sep 26;67(6):1056-8.
  127. Ho JY, Chen MJ, Sheu WH, Tsai AC, Guu HF, Ho ES. Differential effects of oral conjugated equine estrogen and transdermal estrogen on atherosclerotic vascular disease risk markers and endothelial function in healthy postmenopausal women. Hum Reprod. 2006 Oct;21(10):2715-20.
  128. Sheu WH, Chuang SY, Lee WJ, Tsai ST, Chou P, Chen CH. Predictors of incident diabetes, metabolic syndrome in middle-aged adults: a 10-year follow-up study from Kinmen, Taiwan. Diabetes Res Clin Pract. 2006 Nov;74(2):162-8.
  129. Lin MW, Hwu CM, Huang YH, Sheu WH, Rodriguez B, Ho LT. Directly measured insulin resistance and the assessment of clustered cardiovascular risks in hypertension. Am J Hypertens. 2006 Nov;19(11):1118-24.
  130. Tang YJ, Sheu WH, Liu PH, Lee WJ, Chen YT. Positive associations of bone mineral density with body mass index, physical activity, and blood triglyceride level in men over 70 years old: a TCVGHAGE study. J Bone Miner Metab. 2007;25(1):54-9.
  131. Chuo LJ, Sheu WH, Pai MC, Kuo YM. Genotype and plasma concentration of cystatin C in patients with late-onset Alzheimer disease. Dement Geriatr Cogn Disord. 2007;23(4):251-7.
  132. Nestel P, Lyu R, Sheu WH, Nitiyanant W, Saito I, Tan CE. Metabolic syndrome: recent prevalence in East and Southeast Asian populations. Asia Pac J Clin Nutr. 2007;16(2):362-7.
  133. Hsieh CH, Hung YJ, Sheu WH, Yeh KH, Chen CY, Pei D. Impact of clinical characteristics of individual metabolic syndrome on the severity of insulin resistance in Chinese adults. J Korean Med Sci. 2007 Feb;22(1):74-80.
  134. Huang SC, Wu VC, Chou G, Huang TY, Lin SY, Sheu WH. Benign parathyroid adenoma presenting with unusual parathyroid crisis, anemia and myelofibrosis. J Formos Med Assoc. 2007 Feb;106(2 Suppl):S13-6.
  135. Hsu CW, Chen HH, Sheu WH, Shen YS, Wu CP, Chien KL. Initial serum glucose level as a prognostic factor in the first acute myocardial infarction. Ann Emerg Med. 2007 May;49(5):618-26.
  136. Ou HC, Chou FP, Sheu WH, Hsu SL, Lee WJ. Protective effects of magnolol against oxidized LDL-induced apoptosis in endothelial cells. Arch Toxicol. 2007 Jun;81(6):421-32.
  137. Tang YJ, Lee WJ, Chen YT, Liu PH, Lee MC, Sheu WH*. Serum testosterone level and related metabolic factors in men over 70 years old. J Endocrinol Invest. 2007 Jun;30(6):451-8.
  138. Sheu WH*, Chen YD, Yu CY, Lee WJ, Chen YT, Rotter JI. C-reactive protein gene polymorphism 1009A>G is associated with serum CRP levels in Chinese men: a TCVGHAGE study. Clin Chim Acta. 2007 Jul;382(1-2):117-23.
  139. Lin JW, Sheu WH, Lee WJ, Chen YT, Liu TJ, Ting CT, Lee WL. Circulating hepatocyte growth factor level but not basic fibroblast growth factor level is elevated in angiography-proven symptomatic peripheral artery disease. Angiology. 2007 Aug-Sep;58(4):420-8.
  140. Hung YJ, Hsieh CH, Chen YJ, Shen DC, Sheu WH, Chen YC. Insulin sensitivity, proinflammatory markers and adiponectin in young males with different subtypes of depressive disorder. Clin Endocrinol (Oxf). 2007 Nov;67(5):784-9.
  141. Chien HH, Chang CT, Chu NF, Lee IT, Tang YJ, Sheu WH*. Effect of glyburide-metformin combination tablet in patients with type 2 diabetes. J Chin Med Assoc. 2007 Nov;70(11):473-80.
  142. Liang KW, Lee WJ, Lee WL, Chen YT, Ting CT, Sheu WH*. Diabetes exacerbates angiographic coronary lesion progression in subjects with metabolic syndrome independent of CRP levels. Clin Chim Acta. 2008 Feb;388(1-2):41-5.
  143. Lee IT, Huang CN, Lee WJ, Lee HS, Sheu WH*. High total-to-HDL cholesterol ratio predicting deterioration of ankle brachial index in Asian type 2 diabetic subjects. Diabetes Res Clin Pract. 2008 Mar;79(3):419-26.
  144. Lee WJ, Lee WL, Tang YJ, Chien YH, Tsou SS, Sheu WH*. Early Improvements in insulin sensitivity and inflammatory markers are induced by pravastatin in nondiabetic subjects with hypercholesterolemia. Clin Chim Acta. 2008 Apr;390(1-2):49-55.
  145. Li HY, Chiu YF, Sheu WH, Curb JD, Tai TY, Chuang LM. The negative correlation between plasma adiponectin and blood pressure depends on obesity: a family-based association study in SAPPHIRe. Am J Hypertens. 2008 Apr;21(4):471-6.
  146. Sung SH, Chuang SY, Sheu WH, Lee WJ, Chou P, Chen CH. Adiponectin, but not leptin or high-sensitivity C-reactive protein, is associated with blood pressure independently of general and abdominal adiposity. Hypertens Res. 2008 Apr;31(4):633-40.
  147. Sheu WH*, Chang TM, Lee WJ, Wu CS, Wan CJ, Lee IT. Effect of weight loss on proinflammatory state of mononuclear cells in obese women. Obesity (Silver Spring). 2008 May;16(5):1033-8.
  148. Wu MC, Lee WJ, Tschen SM, Liu YM, Chen BY, Sheu WH*. Predictors of mortality in hospitalized diabetic patients: A 7-year prospective study. Diabetes Res Clin Pract. 2008 Jun;80(3):449-54.
  149. Lee IT, Huang CN, Lee WJ, Lee HS, Sheu WH*. Aggravation of albuminuria by metabolic syndrome in type 2 diabetic Asian subjects. Diabetes Res Clin Pract. 2008 Sep;81(3):345-50.
  150. Liang KW, Sheu WH, Lee WL, Wang KY, Chen YT, Lee WJ. Decreased circulating protective adiponectin level is associated with angiographic coronary disease progression in patients with angina pectoris. Int J Cardiol. 2008 Sep 16;129(1):76-80.
  151. Sheu WH, Lee IT, Chen W, Chan YC. Effects of xylooligosaccharides in type 2 diabetes mellitus. J Nutr Sci Vitaminol (Tokyo). 2008 Oct;54(5):396-401.
  152. Lee IT, Chan YC, Lin CW, Lee WJ, Sheu WH*. Effect of cranberry extracts on lipid profiles in subjects with Type 2 diabetes. Diabet Med. 2008 Dec;25(12):1473-7.
  153. Huang SC, Wu VC, Sheu WH, Lin YH, Wu CC, Chang WD. Factors related to clinical hypothyroid severity in thyroid cancer patients after thyroid hormone withdrawal. Thyroid. 2009 Jan;19(1):13-20.
  154. Lee IT, Lee WJ, Ou HC, Huang CN, Sheu WH*. Metabolic syndrome abating the beneficial effect of pravastatin treatment on adhesion of endothelium by monocytes in subjects with hypercholesterolemia. Metabolism. 2009 Mar;58(3):416-20.
  155. Lee WJ, Wu CS, Lin H, Lee IT, Chou MM, Sheu WH*. Visfatin-induced expression of inflammatory mediators in human endothelial cells through the NF-kappaB pathway. Int J Obes (Lond). 2009 Apr;33(4):465-72.
  156. Ou HC, Lee WJ, Lee IT, Chiu TH, Tsai KL, Lin CY, Sheu WH*. Ginkgo biloba extract attenuates oxLDL-induced oxidative functional damages in endothelial cells. J Appl Physiol (1985). 2009 May;106(5):1674-85.
  157. Wang JS, Lin SY, Sheu WH, Lee IT, Tseng LN, Song YM. Effects of patient volume on quality of outpatient diabetes care. Diabetes Res Clin Pract. 2009 May;84(2):e27-9.
  158. Yu NC, Su HY, Tsai ST, Lin BJ, Shiu RS, Hsieh YC, Sheu WH*. ABC control of diabetes: survey data from National Diabetes Health Promotion Centers in Taiwan. Diabetes Res Clin Pract. 2009 May;84(2):194-200.
  159. Sung SH, Chuang SY, Sheu WH, Lee WJ, Chou P, Chen CH. Relation of adiponectin and high-sensitivity C-reactive protein to pulse-wave velocity and N-terminal pro-B-type natriuretic peptide in the general population. Am J Cardiol. 2009 May 15;103(10):1411-6.
  160. Liang KW, Lee WJ, Lee WL, Ting CT, Sheu WH*. Decreased ratio of high-molecular-weight to total adiponectin is associated with angiographic coronary atherosclerosis severity but not restenosis. Clin Chim Acta. 2009 Jul;405(1-2):114-8.
  161. Lin YY, Hsu CW, Sheu WH, Chu SJ, Wu CP, Tsai SH. Use of therapeutic responses to glucose replacement to predict glucose patterns in diabetic patients presenting with severe hypoglycaemia. Int J Clin Pract. 2009 Aug;63(8):1161-6.
  162. Lee IT, Liu HC, Liau YJ, Lee WJ, Huang CN, Sheu WH*. Improvement in health-related quality of life, independent of fasting glucose concentration, via insulin pen device in diabetic patients. J Eval Clin Pract. 2009 Aug;15(4):699-703.
  163. Tseng YH, Huang KC, Liu ML, Shu WT, Sheu WH. Association between metabolic syndrome (MS) and bone mineral loss: a cross-sectional study in Puli Township in Taiwan. Arch Gerontol Geriatr. 2009 Dec;49 Suppl 2:S37-40.
  164. Chou YY, Sheu WH, Tang YJ, Chuang YW, Lin CS, Chen DY. Plasminogen activator inhibitor type 1 (PAI-1) is a valuable biomarker for predicting the metabolic syndrome (MS) in institutionalized elderly residents in Taiwan. Arch Gerontol Geriatr. 2009 Dec;49 Suppl 2:S41-5.
  165. Chang CH, Chen YM, Chuang YW, Tang YJ, Sheu WH, Chen DY. Relationship between hyperuricemia (HUC) and metabolic syndrome (MS) in institutionalized elderly men. Arch Gerontol Geriatr. 2009 Dec;49 Suppl 2:S46-9.
  166. Lee WJ, Ou HC, Wu CM, Lee IT, Lee SD, Sheu WH*. Sesamin mitigates inflammation and oxidative stress in endothelial cells exposed to oxidized low-density lipoprotein. J Agric Food Chem. 2009 Dec 9;57(23):11406-17.
  167. Lin SY, Huang SC, Sheu WH. Circulating adiponectin concentrations were related to free thyroxine levels in thyroid cancer patients after thyroid hormone withdrawal. Metabolism. 2010 Feb;59(2):195-9.
  168. Lee IT, Liau YJ, Lee WJ, Huang CN, Sheu WH*. Continuous subcutaneous insulin infusion providing better glycemic control and quality of life in Type 2 diabetic subjects hospitalized for marked hyperglycemia. J Eval Clin Pract. 2010 Feb;16(1):202-5.
  169. Wang YY, Lin SY, Chuang YH, Mao CH, Tung KC, Sheu WH. Protein nitration is associated with increased proteolysis in skeletal muscle of bile duct ligation-induced cirrhotic rats. Metabolism. 2010 Apr;59(4):468-72.
  170. Wang YY, Lin SY, Sheu WH, Liu PH, Tung KC. Obesity and diabetic hyperglycemia were associated with serum alanine aminotransferase activity in patients with hepatitis B infection. Metabolism. 2010 Apr;59(4):486-91.
  171. Lin YY, Hsu CW, Sheu WH, Chu SJ, Wu CP, Tsai SH. Risk factors for recurrent hypoglycemia in hospitalized diabetic patients admitted for severe hypoglycemia. Yonsei Med J. 2010 May;51(3):367-74.
  172. Chang CH, Shau WY, Sheu WH, Kwok CF, Ho LT, Chuang LM. Type 2 diabetes prevalence and incidence among adults in Taiwan during 1999-2004: a national health insurance data set study. Diabet Med. 2010 Jun;27(6):636-43.
  173. Chang YC, Chiu YF, Sheu WH, Chang TJ, Li HY, Chuang LM. Common PCSK1 haplotypes are associated with obesity in the Chinese population. Obesity (Silver Spring). 2010 Jul;18(7):1404-9.
  174. Lee IT, Lee WJ, Sheu WH*. Metabolic syndrome exacerbating ankle-brachial index in asian type 2 diabetic patients. Angiology. 2010 Jul;61(5):482-6.
  175. Chan SP, Ji LN, Nitiyanant W, Baik SH, Sheu WH. Hypoglycemic symptoms in patients with type 2 diabetes in Asia-Pacific-Real-life effectiveness and care patterns of diabetes management: the RECAP-DM study. Diabetes Res Clin Pract. 2010 Aug;89(2):e30-2.
  176. Chen YM, Chen HH, Lan JL, Chen DY, Sheu WH. Nodular mucinosis in Graves disease mimicking gouty tophi. J Clin Rheumatol. 2010 Sep;16(6):287-9.
  177. Ou HC, Lee WJ, Lee SD, Hsu WC, Sheu WH*. Ellagic acid protects endothelial cells from oxidized low-density lipoprotein-induced apoptosis by modulating the PI3K/Akt/eNOS pathway. Toxicol Appl Pharmacol. 2010 Oct 15;248(2):134-43.
  178. Lee WJ, Ou HC, Hsu SL, Tsai KL, Sheu WH*. Ellagic acid inhibits oxidized LDL-mediated LOX-1 expression, ROS generation, and inflammation in human endothelial cells. J Vasc Surg. 2010 Nov;52(5):1290-300.
  179. Wan CJ, Lin LY, Yu TH, Sheu WH*. Metabolic syndrome associated with habitual indulgence and dietary behavior in middle-aged health-care professionals. J Diabetes Investig. 2010 Dec 3;1(6):259-65.
  180. Tsai HJ, Hsiao CF, Ho LT, Quertermos T, Hsiung CA, Sheu WH*. Genetic variants of human urea transporter-2 are associated with metabolic syndrome in Asian population. Clin Chim Acta. 2010 Dec 14;411(23-24):2009-13.
  181. Wang YY, Lin SY, Chuang YH, Chen CJ, Tung KC, Sheu WH. Adipose proinflammatory cytokine expression through sympathetic system is associated with hyperglycemia and insulin resistance in a rat ischemic stroke model. Am J Physiol Endocrinol Metab. 2011 Jan;300(1):E155-63.
  182. Wang TD, Sheu WH*. From casual blood pressure measurement to long-term blood pressure burden: better elucidation of the association between versatile blood pressures and cardiovascular events. Hypertens Res. 2011 Jan;34(1):49-51.
  183. Wang JS, Tu ST, Lee IT, Lin SD, Lin SY, Su SL, Lee WJ, SheuWH*. Contribution of postprandial glucose to excess hyperglycaemia in Asian type 2 diabetic patients using continuous glucose monitoring. Diabetes Metab Res Rev. 2011 Jan;27(1):79-84.
  184. Chiang SC, Lee JK, Sheu WH, Juang JH, Wang CY, Ho LT. Justifying the high prevalence of microalbuminuria for type 2 diabetic patients in Taiwan with conditional probability approach--a DEMAND II study. J Chin Med Assoc. 2011 Jan;74(1):3-10.
  185. Sheen YJ, Sheu WH*. Metabolic syndrome and renal injury. Cardiol Res Pract. 2011 Mar 13;2011:567389.
  186. Sheu WH, Chuang HC, Cheng SM, Lee MR, Chou CC, Cheng FC. Microdialysis combined blood sampling technique for the determination of rosiglitazone and glucose in brain and blood of gerbils subjected to cerebral ischemia. J Pharm Biomed Anal. 2011 Mar 25;54(4):759-64.
  187. Lang HF, Chou CY, Sheu WH*, Lin JY. Weight loss increased serum adiponectin but decreased lipid levels in obese subjects whose body mass index was lower than 30 kg/m². Nutr Res. 2011 May;31(5):378-86.
  188. Kuo MY, Ou HC, Lee WJ, Tsai KL, Tsai CS, Sheu WH*. Ellagic acid inhibits oxidized low-density lipoprotein (OxLDL)-induced metalloproteinase (MMP) expression by modulating the protein kinase C-α/extracellular signal-regulated kinase/peroxisome proliferator-activated receptor γ/nuclear factor-κB (PKC-α/ERK/PPAR-γ/NF-κB) signaling pathway in endothelial cells. J Agric Food Chem. 2011 May 11;59(9):5100-8.
  189. Sheu WH*, Rosman A, Mithal A, Lee MK, Yoon KH, Schnell O. Addressing the burden of type 2 diabetes and cardiovascular disease through the management of postprandial hyperglycaemia: an Asian-Pacific perspective and expert recommendations. Diabetes Res Clin Pract. 2011 Jun;92(3):312-21.
  190. Sheu WH*. Alteration of insulin sensitivity by sex hormones during the menstrual cycle. J Diabetes Investig. 2011 Aug 2;2(4):258-9.
  191. Lin SD, Wang JS, Sheu WH, Lin SY, Wang SY, Hsieh MC. The beneficial effect of α-glucosidase inhibitor on glucose variability compared with sulfonylurea in Taiwanese type 2 diabetic patients inadequately controlled with metformin: preliminary data. J Diabetes Complications. 2011 Sep-Oct;25(5):332-8.
  192. Liang KW, Lee WJ, Lee IT, Fu CP, Ting CT, Sheu WH*. Persistent elevation of paraoxonase-1 specific enzyme activity after weight reduction in obese non-diabetic men with metabolic syndrome. Clin Chim Acta. 2011 Sep 18;412(19-20):1835-41.
  193. Chan JC, Chan SP, Pan CY, Sheu WH, Barter P. Diabetic dyslipidaemia in Asian populations in the Western Pacific Region: what we know and don't know. Diabetes Res Clin Pract. 2011 Oct;94(1):1-13.
  194. Wang JS, Lin SD, Lee WJ, Tseng YH, Lin SY, Sheu WH*. Effects of acarbose versus glibenclamide on glycemic excursion and oxidative stress in type 2 diabetic patients inadequately controlled by metformin: a 24-week, randomized, open-label, parallel-group comparison. Clin Ther. 2011 Dec;33(12):1932-42.
  195. Sheen YJ, Lin JL, Lee IT, Hsu YN, Li TC, Sheu WH*. Low estimated glomerular filtration rate is a major determinant of low ankle-brachial index and toe-brachial index in type 2 diabetes. Angiology. 2012 Jan;63(1):55-61.
  196. Weng SC, Shu KH, Sheu WH, Wu MJ, Chen YM, Chuang YW. Progression of cognitive dysfunction in elderly chronic kidney disease patients in a veteran's institution in central Taiwan: a 3-year longitudinal study. Intern Med. 2012;51(1):29-35.
  197. Mu YM, Misra A, Adam JM, Khue NT, Sheu WH, Tan KE. Managing diabetes in Asia: overcoming obstacles and the role of DPP-IV inhibitors. Diabetes Res Clin Pract. 2012 Feb;95(2):179-88.
  198. Lee IT, Lee WJ, Tsai CM, Su IJ, Yen HT, Sheu WH*. Combined extractives of red yeast rice, bitter gourd, chlorella, soy protein, and licorice improve total cholesterol, low-density lipoprotein cholesterol, and triglyceride in subjects with metabolic syndrome. Nutr Res. 2012 Feb;32(2):85-92.
  199. Liang KW, Tsai IC, Lee WJ, Wan CJ, Fu CP, Ting CT, Sheu WH*. MRI measured epicardial adipose tissue thickness at the right AV groove differentiates inflammatory status in obese men with metabolic syndrome. Obesity (Silver Spring). 2012 Mar;20(3):525-32.
  200. Chang YC, Chiu YF, Sheu WH, Lee PC, Chen YT, Chuang LM. Replication of genome-wide association signals of type 2 diabetes in Han Chinese in a prospective cohort. Clin Endocrinol (Oxf). 2012 Mar;76(3):365-72.
  201. Ou HC, Lee WJ, Wu CM, Chen JF, Sheu WH*. Aspirin prevents resistin-induced endothelial dysfunction by modulating AMPK, ROS, and Akt/eNOS signaling. J Vasc Surg. 2012 Apr;55(4):1104-15.
  202. Su HY, Tsang MW, Huang SY, Sheu WH*, Marchetti A. Transculturalization of a diabetes-specific nutrition algorithm: Asian application. Curr Diab Rep. 2012 Apr;12(2):213-9.
  203. Mechanick JI, Marchetti AE, Sheu WH, Tsang MW, Hamdy O. Diabetes-specific nutrition algorithm: a transcultural program to optimize diabetes and prediabetes care. Curr Diab Rep. 2012 Apr;12(2):180-94.
  204. Lee IT, Chiu YF, Hwu CM, Lin YC, Assimes T, Curb JD, Sheu WH*.Central obesity is important but not essential component of the metabolic syndrome for predicting diabetes mellitus in a hypertensive family-based cohort. Results from the Stanford Asia-pacific program for hypertension and insulin resistance (SAPPHIRe) Taiwan follow-up study.Cardiovasc Diabetol. 2012 Apr 26;11:43.
  205. Sheu WH, Ji LN, Nitiyanant W, Yin D, Mavros P, Chan SP. Hypoglycemia is associated with increased worry and lower quality of life among patients with type 2 diabetes treated with oral antihyperglycemic agents in the Asia-Pacific region. Diabetes Res Clin Pract. 2012 May;96(2):141-8.
  206. Lee IT, Lee WJ, Tsai IC, Wan CJ, Fu CP, Sheu WH*. Brain-derived neurotrophic factor not associated with metabolic syndrome but inversely correlated with vascular cell adhesion molecule-1 in men without diabetes. Clin Chim Acta. 2012 May 18;413(9-10):944-8.
  207. Sheen YJ, Sheu WH*. Links among type 2 diabetes, cancer and metformin use: what have we learned? Diabetes Res Clin Pract. 2012 Aug;97(2):169-71.
  208. Lee IT, Hung YJ, Chen JF, Wang CY, Lee WJ, Sheu WH*. Comparison of the efficacy and safety profiles of two fixed-dose combinations of antihypertensive agents, amlodipine/benazepril versus valsartan/hydrochlorothiazide, in patients with type 2 diabetes mellitus and hypertension: a 16-week, multicenter, randomized, double-blind, noninferiority study. Clin Ther. 2012 Aug;34(8):1735-50.
  209. Sheu WH*. Addressing self-monitoring of blood glucose: Advocating paired glycemic testing for people with type 2 diabetes. J Diabetes Investig. 2012 Aug 20;3(4):337-8.
  210. Wang CY, Lin CL, Huang TS, Kwok CF, Fu CC, Sheu WH. Inertia on hypoglycemia: highlight from a Taiwan subgroup analysis of Real-Life Effectiveness and Care Patterns of Diabetes Management (RECAP-DM) study. Diabetes Res Clin Pract. 2012 Oct;98(1):61-7.
  211. Fu CP, Lee IT, Sheu WH, Lee WJ, Liang KW, Lee WL, Lin SY. The levels of circulating and urinary monocyte chemoattractant protein-1 are associated with chronic renal injury in obese men. Clin Chim Acta. 2012 Oct 9;413(19-20):1647-51.
  212. Tseng LN, Tseng YH, Jiang YD, Chuang LM, Tai TY, Sheu WH*. Prevalence of hypertension and dyslipidemia and their associations with micro- and macrovascular diseases in patients with diabetes in Taiwan: an analysis of nationwide data for 2000-2009. J Formos Med Assoc. 2012 Nov;111(11):625-36.
  213. Parving HH, Brenner BM, McMurray JJ; ALTITUDE Investigators(Sheu WH). Cardiorenal end points in a trial of aliskiren for type 2 diabetes. N Engl J Med. 2012 Dec 6;367(23):2204-13.
  214. Lin CH, Sheu WH*. Hypoglycaemic episodes and risk of dementia in diabetes mellitus: 7-year follow-up study. J Intern Med. 2013 Jan;273(1):102-10.
  215. Weng SC, Shu KH, Tarng DC, Huang ST, Sheu WH, Wu MJ. In-hospital mortality risk estimation in patients with acute nonvariceal upper gastrointestinal bleeding undergoing hemodialysis: a retrospective cohort study. Ren Fail. 2013;35(2):243-8.
  216. Lee CL, Li TC, Lin SY, Wang JS, Tsai SF, Sheu WH*. Dynamic and dual effects of glycated hemoglobin on estimated glomerular filtration rate in type 2 diabetic outpatients. Am J Nephrol. 2013;38(1):19-26.
  217. Chou CY, Lang HF, Sheu WH*, Lin JY. Weight loss improves serum mediators and metabolic syndrome features in android obese subjects. Obes Res Clin Pract. 2013 Jan-Feb;7(1):e81-8.
  218. Sheen YJ, Lin JL, Li TC, Bau CT, Sheu WH*. Peripheral arterial stiffness is independently associated with a rapid decline in estimated glomerular filtration rate in patients with type 2 diabetes. Biomed Res Int. 2013;2013:309294.
  219. Buse JB, Nauck M, Sheu WH, Fineman M, Porter L, Schernthaner G. Exenatide once weekly versus liraglutide once daily in patients with type 2 diabetes (DURATION-6): a randomised, open-label study. Lancet. 2013 Jan 12;381(9861):117-24.
  220. Liao YC, Liang KW, Lee WJ, Wang JS, Ting CT, Sheu WH*. Leptin to adiponectin ratio as a useful predictor for cardiac syndrome X. Biomarkers. 2013 Feb;18(1):44-50.
  221. Yu NC, Su HY, Chiou ST, Yeh MC, Yeh SW, Tzeng MS, Sheu WH*. Trends of ABC control 2006-2011: a National Survey of Diabetes Health Promotion Institutes in Taiwan. Diabetes Res Clin Pract. 2013 Feb;99(2):112-9.
  222. Lu CH, Wu TJ, Shih KC, Yu M, Sheu WH, Chuang LM. Safety and efficacy of twice-daily exenatide in Taiwanese patients with inadequately controlled type 2 diabetes mellitus. J Formos Med Assoc. 2013 Mar;112(3):144-50.
  223. Wu Y, Waite LL, Sheu WH, Hsiung CA, North KE, Mohlke KL. Trans-ethnic fine-mapping of lipid loci identifies population-specific signals and allelic heterogeneity that increases the trait variance explained. PLoS Genet. 2013 Mar;9(3):e1003379.
  224. Wang YY, Chen CJ, Lin SY, Chuang YH, Sheu WH, Tung KC. Hyperglycemia is associated with enhanced gluconeogenesis in a rat model of permanent cerebral ischemia. Mol Cell Endocrinol. 2013 Mar 10;367(1-2):50-6.
  225. Wang JS, Lee IT, Lee WJ, Lee WL, Liang KW, Sheu WH*. Performance of HbA1c and fasting plasma glucose in screening for diabetes in patients undergoing coronary angiography. Diabetes Care. 2013 May;36(5):1138-40.
  226. Lee IT, Wang CY, Huang CN, Fu CC, Sheu WH*. High triglyceride-to-HDL cholesterol ratio associated with albuminuria in type 2 diabetic subjects. J Diabetes Complications. 2013 May-Jun;27(3):243-7.
  227. Liao WI, Sheu WH, Chang WC, Hsu CW, Chen YL, Tsai SH. An elevated gap between admission and A1C-derived average glucose levels is associated with adverse outcomes in diabetic patients with pyogenic liver abscess. PLoS One. 2013 May 28;8(5):e64476.
  228. Liu SH, Sheu WH, Lee MR, Chen WB, Tien HR, Sheu ML. Advanced glycation end product Nε-carboxymethyllysine induces endothelial cell injury: the involvement of SHP-1-regulated VEGFR-2 dephosphorylation. J Pathol. 2013 Jun;230(2):215-27.
  229. Chang YC, Sheu WH, Chien YS, Tseng PC, Lee WJ, Chiang AN. Hyperglycemia accelerates ATP-binding cassette transporter A1 degradation via an ERK-dependent pathway in macrophages. J Cell Biochem. 2013 Jun;114(6):1364-73.
  230. Liang KW, Sheu WH, Lee WL, Lee IT, Lin SY, Ting CT, Lee WJ. Shorter GT repeats in the heme oxygenase-1 gene promoter are associated with a lower severity score in coronary artery disease. J Chin Med Assoc. 2013 Jun;76(6):312-8.
  231. Fu CP, Sheu WH, Lee IT, Liang KW, Lee WL, Lin SY. Effects of weight loss on epicardial adipose tissue thickness and its relationship between serum soluble CD40 ligand levels in obese men. Clin Chim Acta. 2013 Jun 5;421:98-103.
  232. Lin TL, Sheen HM, Chung CT, Chan IC, Shih HS, Sheu WH*. The effect of removing plugs and adding arch support to foam based insoles on plantar pressures in people with diabetic peripheral neuropathy. J Foot Ankle Res. 2013 Jul 29;6(1):29.
  233. Sheu WH, Kuo JZ, Lee IT, Fu CP, Rotter JI, Chen YD. Genome-wide association study in a Chinese population with diabetic retinopathy. Hum Mol Genet. 2013 Aug 1;22(15):3165-73.
  234. Lee WJ, Lan KH, Chou CT, Tien HR, Sheu WH, Sheu ML. Tpl2 inhibitors thwart endothelial cell function in angiogenesis and peritoneal dissemination. Neoplasia. 2013 Sep;15(9):1036-48.
  235. Wang JS, Huang CN, Hung YJ, Chen CC, Lin CL, Sheu WH*. Acarbose plus metformin fixed-dose combination outperforms acarbose monotherapy for type 2 diabetes. Diabetes Res Clin Pract. 2013 Oct;102(1):16-24.
  236. Kalra S, Sahay RK, Sheu WH, Yamamoto N, Weng J, Rathod R. Acarbose improves glycemic control and reduces body weight: Subanalysis data of South Asia region. Indian J Endocrinol Metab. 2013 Oct;17(Suppl 1):S304-6.
  237. Kalra S, Sahay RK, Sheu WH, Yamamoto N, Weng J, Rathod R. Alpha-glucosidase inhibitor, acarbose, improves glycamic control and reduces body weight in type 2 diabetes: Findings on indian patients from the pooled data analysis. Indian J Endocrinol Metab. 2013 Oct;17(Suppl 1):S307-9.
  238. Scirica BM, Bhatt DL; SAVOR-TIMI 53 Steering Committee and Investigators(Sheu WH). Saxagliptin and cardiovascular outcomes in patients with type 2 diabetes mellitus. N Engl J Med. 2013 Oct 3;369(14):1317-26.
  239. Do R, Willer CJ, Schmidt EM, Khaw KT,Sheu WH, et al. Common variants associated with plasma triglycerides and risk for coronary artery disease. Nat Genet. 2013 Nov;45(11):1345-52.
  240. Willer CJ, Schmidt EM, Sengupta S, Khaw KT, Kim E, Sheu WH,et al. Discovery and refinement of loci associated with lipid levels. Nat Genet. 2013 Nov;45(11):1274-1283.
  241. Chang YC, Tsai MH, Sheu WH, Hsieh SC, Chiang AN. The therapeutic potential and mechanisms of action of quercetin in relation to lipopolysaccharide-induced sepsis in vitro and in vivo. PLoS One. 2013 Nov 19;8(11):e80744.
  242. Kuo JZ, Sheu WH, Assimes TL, Quertermous T, Rotter JI, Chen YD. Trans-ethnic fine mapping identifies a novel independent locus at the 3' end of CDKAL1 and novel variants of several susceptibility loci for type 2 diabetes in a Han Chinese population. Diabetologia. 2013 Dec;56(12):2619-28.
  243. Lee IT, Goodarzi MO, Lee WJ, Liang KW, Lee WL, Sheu WH*. The chromosome 9p21 variant not predicting long-term cardiovascular mortality in Chinese with established coronary artery disease: an eleven-year follow-up study. Biomed Res Int. 2014;2014:626907.
  244. Chen JM, Chang CW, Lin YC, Horng JT, Sheu WH*. Acarbose treatment and the risk of cardiovascular disease in type 2 diabetic patients: a nationwide seven-year follow-up study. J Diabetes Res. 2014;2014:812628.
  245. Chen JM, Chang CW, Chang TH, Hsu CC, Horng JT, Sheu WH. Effects of statins on incident dementia in patients with type 2 DM: a population-based retrospective cohort study in Taiwan. PLoS One. 2014 Feb 10;9(2):e88434.
  246. Sheen YJ, Sheu WH*. Improved prediction of cardiovascular events in diabetic patients: Role of quantitative ultrasonic tissue characterization. J Diabetes Investig. 2014 Feb 12;5(1):17-8.
  247. Lee IT, Fu CP, Lee WJ, Liang KW, Lin SY, Wan CJ, Sheu WH*. Brain-derived neurotrophic factor, but not body weight, correlated with a reduction in depression scale scores in men with metabolic syndrome: a prospective weight-reduction study. Diabetol Metab Syndr. 2014 Feb 13;6(1):18.
  248. Wu Y, Gao H, Sheu WH, Lin X, Mohlke KL, Tai ES. A meta-analysis of genome-wide association studies for adiponectin levels in East Asians identifies a novel locus near WDR11-FGFR2. Hum Mol Genet. 2014 Feb 15;23(4):1108-19.
  249. Fu CP, Sheu WH, Tseng JJ, Lin SY. A young male adolescent with feminine appearance: diagnosis of 46, XX syndrome neglected for 4 years with gynaecomastia presentation. Andrologia. 2014 Apr;46(3):325-8.
  250. Wang YY, Lin SY, Chuang YH, Sheu WH, Tung KC, Chen CJ. Activation of hepatic inflammatory pathways by catecholamines is associated with hepatic insulin resistance in male ischemic stroke rats. Endocrinology. 2014 Apr;155(4):1235-46.
  251. Chen PH, Tsai YT, Wang JS, Lin SD, Lee WJ, Sheu WH, Lin SY. Post-meal β-cell function predicts the efficacy of glycemic control in patients with type 2 diabetes inadequately controlled by metformin monotherapy after addition of glibenclamide or acarbose. Diabetol Metab Syndr. 2014 May 31;6:68.
  252. Chen P, Takeuchi F, Sheu WH, Kim BJ, Kato N, Tai ES. Multiple nonglycemic genomic loci are newly associated with blood level of glycated hemoglobin in East Asians. Diabetes. 2014 Jul;63(7):2551-62.
  253. Wang JY, Lee SH, Lee IT, Chen JD, Sheu WH*. Effect of prescription refill on quality of care among patients with type 2 diabetes: an exploratory study. Diabetes Res Clin Pract. 2014 Jul;105(1):110-8.
  254. Chuang HC, Sheu WH, Lin YT, Xie M, Schneider MD, Tan TH. HGK/MAP4K4 deficiency induces TRAF2 stabilization and Th17 differentiation leading to insulin resistance. Nat Commun. 2014 Aug 6;5:4602.
  255. Lee WJ, Sheu WH, Liu SH, Lee MR, Yang TJ, Sheu ML. Nε-carboxymethyllysine-mediated endoplasmic reticulum stress promotes endothelial cell injury through Nox4/MKP-3 interaction. Free Radic Biol Med. 2014 Sep;74:294-306.
  256. Lin YF, Sheu WH*. From sugar to kidney: A never-ending battle. J Diabetes Investig. 2014 Sep;5(5):482-3.
  257. Chang CY, Shen CY, Sheu WH, Chang CC, Lee TH. Taurine protects HK-2 cells from oxidized LDL-induced cytotoxicity via the ROS-mediated mitochondrial and p53-related apoptotic pathways. Toxicol Appl Pharmacol. 2014 Sep 15;279(3):351-363.
  258. Wen W, Zheng W, Sheu WH, Wu T, Mohlke KL, Gu D, et al. Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index. Hum Mol Genet. 2014 Oct 15;23(20):5492-504.
  259. Liang KW, Tsai IC, Lee WJ, Fu CP, Wang JS, Sheu WH*. Correlation between reduction of superior interventricular groove epicardial fat thickness and improvement of insulin resistance after weight loss in obese men. Diabetol Metab Syndr. 2014 Oct 29;6(1):115.
  260. Gough SC, Bode B, Woo V; NN9068-3697 (DUAL-I) trial investigators(Sheu WH). Efficacy and safety of a fixed-ratio combination of insulin degludec and liraglutide (IDegLira) compared with its components given alone: results of a phase 3, open-label, randomised, 26-week, treat-to-target trial in insulin-naive patients with type 2 diabetes. Lancet Diabetes Endocrinol. 2014 Nov;2(11):885-93.
  261. Sheen YJ, Lin JL, Li TC, Bau CT, Sheu WH*. Systolic blood pressure as a predictor of incident albuminuria and rapid renal function decline in type 2 diabetic patients. J Diabetes Complications. 2014 Nov-Dec;28(6):779-84.
  262. Chen PH, Wang JS, Hwang JI, Sheu WH, Peng CM, Lee IT. nsulinoma in a young female patient with systemic lupus erythematosus: a case report. Endocr Pract. 2014 Dec;20(12):e256-9.
  263. Wang CY, Yu NC, Sheu WH, Tsai ST, Tai TY. Team care of type 2 diabetes mellitus in Taiwan. Diabetes Res Clin Pract. 2014 Dec;106 Suppl 2:S309-13.
  264. Sheen YJ, Sheu WH. Risks of rapid decline renal function in patients with type 2 diabetes. World J Diabetes. 2014 Dec 15;5(6):835-46.
  265. Lee IT, Sheu WH, Hung YJ, Chen JF, Wang CY, Lee WJ. Assessment of glomerular filtration rate based on alterations of serum brain-derived neurotrophic factor in type 2 diabetic subjects treated with amlodipine/benazepril or valsartan/hydrochlorothiazide. Dis Markers. 2015;2015:780743.
  266. Wessel J, Chu AY, Malerba G, Sheu WH, et al. Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility. Nat Commun. 2015 Jan 29;6:5897.
  267. Weng J, Soegondo S, Sheu WH, Watada H, Yamamoto N, Kalra S. Efficacy of acarbose in different geographical regions of the world: analysis of a real-life database. Diabetes Metab Res Rev. 2015 Feb;31(2):155-67.
  268. Huang CY, Chen WM, Tsay YG, Lee WJ, Sheu WH*, Chiang AN. Differential regulation of protein expression in response to polyunsaturated fatty acids in the liver of apoE-knockout mice and in HepG2 cells. J Biomed Sci. 2015 Feb 7;22(1):12.
  269. Shungin D, Winkler TW, Hallmans G, Sheu WH, et al. New genetic loci link adipose and insulin biology to body fat distribution. Nature. 2015 Feb 12;518(7538):187-196.
  270. Locke AE, Kahali B, Dimitriou M, Sheu WH, et al. Genetic studies of body mass index yield new insights for obesity biology. Nature. 2015 Feb 12;518(7538):197-206.
  271. Tsai WN, Wang YY, Liang JT, Lin SY, Sheu WH, Chang WD. Serum total bilirubin concentrations are inversely associated with total white blood cell counts in an adult population. Ann Clin Biochem. 2015 Mar;52(Pt 2):251-8.
  272. Fu CP, Sheu WH, Lee IT, Liang KW, Lee WL, Lin SY. Weight loss reduces serum monocyte chemoattractant protein-1 concentrations in association with improvements in renal injury in obese men with metabolic syndrome. Clin Chem Lab Med. 2015 Mar;53(4):623-9.
  273. Hsu CR, Chen YT, Sheu WH*. Glycemic variability and diabetes retinopathy: a missing link. J Diabetes Complications. 2015 Mar;29(2):302-6.
  274. Sheu WH*, Park SW, Gong Y, Patel S, Seck T, Woerle HJ. Linagliptin improves glycemic control after 1 year as add-on therapy to basal insulin in Asian patients with type 2 diabetes mellitus. Curr Med Res Opin. 2015 Mar;31(3):503-12.
  275. Huang CY, Sheu WH, Chiang AN. Docosahexaenoic acid and eicosapentaenoic acid suppress adhesion molecule expression in human aortic endothelial cells via differential mechanisms. Mol Nutr Food Res. 2015 Apr;59(4):751-62.
  276. Chuang SY, Yu Y, Sheu WH, Liu X, Hsiung CA, Tsai HJ. Association of short-term use of nonsteroidal anti-inflammatory drugs with stroke in patients with hypertension. Stroke. 2015 Apr;46(4):996-1003.
  277. Leibowitz G, Cahn A, Sheu WH, Braunwald E, Scirica BM, Raz I. Impact of treatment with saxagliptin on glycaemic stability and β-cell function in the SAVOR-TIMI 53 study. Diabetes Obes Metab. 2015 May;17(5):487-94.
  278. Pan HC, Sheu WH, Lee WJ, Lee IT, Wang JS, Liang KW. Coronary severity score and C-reactive protein predict major adverse cardiovascular events in patients with stable coronary artery disease (from the Taichung CAD study). Clin Chim Acta. 2015 May 20;445:93-100.
  279. Green JB, Bethel MA; TECOS Study Group(Sheu WH). Effect of Sitagliptin on Cardiovascular Outcomes in Type 2 Diabetes. N Engl J Med. 2015 Jul 16;373(3):232-42.
  280. Wang JS, Lee IT, Lee WJ, Lin SY, Fu CP, Lee WL, Liang KW, Sheu WH*. Comparing HbA1c, fasting and 2-h plasma glucose for screening for abnormal glucose regulation in patients undergoing coronary angiography. Clin Chem Lab Med. 2015 Aug;53(9):1441-9.
  281. Lin TT, Lin CH, Chang CL, Chi CH, Chang ST, Sheu WH*. The effect of diabetes, hyperlipidemia, and statins on the development of rotator cuff disease: a nationwide, 11-year, longitudinal, population-based follow-up study. Am J Sports Med. 2015 Sep;43(9):2126-32.
  282. Lee IT, Liang KW, Wang JS, Lee WJ, Chen YI, Lin SY, Lee WL, Sheu WH*. Value of Chromosome 9p21 Polymorphism for Prediction of Cardiovascular Mortality in Han Chinese Without Coronary Lesions: An Observational Study. Medicine (Baltimore). 2015 Sep;94(39):e1538.
  283. Liang KW, Lee WJ, Lee IT, Wang JS, Sheu WH*. Circulating adipokines and insulin resistance in subjects with combined cardiac and metabolic syndrome X. Diabetol Metab Syndr. 2015 Sep 24;7:83.
  284. Hu CY, Lee CL, Sheu WH, Ling JT, Li YF, Lin SY. A new formula for estimation of low-density lipoprotein cholesterol in an ethnic Chinese population. Clin Chem Lab Med. 2015 Oct;53(11):1871-9.
  285. Lee AT, Wang YY, Sheu WH, Song YM, Chang WD. Higher serum total bilirubin concentration is associated with lower risk of renal insufficiency in an adult population. Int J Clin Exp Med. 2015 Oct 15;8(10):19212-22.
  286. Wang JS, Lee CL, Lee WJ, Liang KW, Sheu WH*. Factors associated with fibroblast growth factor 19 increment after oral glucose loading in patients who were previously admitted for coronary angiography. Clin Chim Acta. 2015 Oct 23;450:237-42.
  287. Tseng YH, Tsan YT, Chan WC, Sheu WH, Chen PC. Use of an α-Glucosidase Inhibitor and the Risk of Colorectal Cancer in Patients With Diabetes: A Nationwide, Population-Based Cohort Study. Diabetes Care. 2015 Nov;38(11):2068-74.
  288. Sheu WH, Gantz I, Chen M, Goldstein BJ, Kaufman KD, Engel SS. Safety and Efficacy of Omarigliptin (MK-3102), a Novel Once-Weekly DPP-4 Inhibitor for the Treatment of Patients With Type 2 Diabetes. Diabetes Care. 2015 Nov;38(11):2106-14.
  289. Su CS, Chen KJ, Sheu WH*, Wang KY, Lee WL. Lack of Association between High-Density Lipoprotein Cholesterol and Angiographic Coronary Lesion Severity in Chinese Patients with Low Background Low-Density Lipoprotein Cholesterol. Acta Cardiol Sin. 2015 Nov;31(6):528-35.
  290. Chang TJ, Chiu YF, Sheu WH, Kuo SS, Chang YC, Chuang LM. Genetic polymorphisms of PCSK2 are associated with glucose homeostasis and progression to type 2 diabetes in a Chinese population. Sci Rep. 2015 Nov 26;5:14380.
  291. Ke CC, Lai HC, Lin CH, Hung CJ, Chen DY, Sheu WH, Lui PW. Increased Risk of Herpes Zoster in Diabetic Patients Comorbid with Coronary Artery Disease and Microvascular Disorders: A Population-Based Study in Taiwan. PLoS One. 2016 Jan 11;11(1):e0146750.
  292. Lee CL, Wang JS, Lee IT, Lin SY, Li YF, Sheu WH*. Association of MMP-9 to TIMP-1 ratio with long-term body weight and waist circumference after dietary weight reduction in men with metabolic syndrome. Clin Chim Acta. 2016 Jan 15;452:182-4.
  293. Lee WJ, Liu SH, Chiang CK, Chang YC, Sheu WH*, Sheu ML. Aryl Hydrocarbon Receptor Deficiency Attenuates Oxidative Stress-Related Mesangial Cell Activation and Macrophage Infiltration and Extracellular Matrix Accumulation in Diabetic Nephropathy. Antioxid Redox Signal. 2016 Feb 1;24(4):217-231.
  294. Lee IT, Sheu WH, Lin SY. The Impact of Creatinine Clearance Rate, Daily Urinary Albumin, and Their Joint Effect on Predicting Death in Diabetic Inpatients After Discharge: An Observational Study. Medicine (Baltimore). 2016 Feb;95(6):e2804.
  295. Wang HF, Yu NC, Sheu WH, Yeh MC. The development of a questionnaire measure of diabetes-related distress in Chinese-speaking patients: the Diabetes-Related Distress Questionnaire (DRDQ). Qual Life Res. 2016 Mar;25(3):721-9.
  296. Wang JS, Lee IT, Tseng YH, Lin SY, Sheu WH*. Glycemic excursions are positively associated with changes in duration of asymptomatic hypoglycemia after treatment intensification in patients with type 2 diabetes. Diabetes Res Clin Pract. 2016 Mar;113:108-15.
  297. Chang TJ, Wang WC, Hsiung CA, Sheu WH; and the SAPPHIRe Study Group. Genetic Variation in the Human SORBS1 Gene is Associated With Blood Pressure Regulation and Age at Onset of Hypertension: A SAPPHIRe Cohort Study. Medicine (Baltimore). 2016 Mar;95(10):e2970.
  298. Chuang HC, Wang JS, Lee IT, Sheu WH, Tan TH. Epigenetic regulation of HGK/MAP4K4 in T cells of type 2 diabetes patients. Oncotarget. 2016 Mar 8;7(10):10976-89.
  299. Zanoni P, Khetarpal SA; Global Lipids Genetics Consortium(Sheu WH). Rare variant in scavenger receptor BI raises HDL cholesterol and increases risk of coronary heart disease. Science. 2016 Mar 11;351(6278):1166-71.
  300. Assimes TL, Lee IT, Sheu WH, Chen YD, Taylor KD. Genetics of Coronary Artery Disease in Taiwan: A Cardiometabochip Study by the Taichi Consortium. PLoS One. 2016 Mar 16;11(3):e0138014.
  301. Li YH, Lin SY, Sheu WH, Lee IT. Relationship between percentage of mean arterial pressure at the ankle and mortality in participants with normal ankle-brachial index: an observational study. BMJ Open. 2016 Mar 25;6(3):e010540.
  302. Sheu WH*, Brunell SC, Blase E. Efficacy and tolerability of exenatide twice daily and exenatide once weekly in Asian versus White patients with type 2 diabetes mellitus: A pooled analysis. Diabetes Res Clin Pract. 2016 Apr;114:160-72.
  303. Schnell O, Weng J, Sheu WH, Rathod R, Zhang C, Grzeszczak W. Acarbose reduces body weight irrespective of glycemic control in patients with diabetes: results of a worldwide, non-interventional, observational study data pool. J Diabetes Complications. 2016 May-Jun;30(4):628-37.
  304. Chen WM, Sheu WH*, Lee WJ, Chang PJ, Chiang AN. Modulation of microRNA Expression in Subjects with Metabolic Syndrome and Decrease of Cholesterol Efflux from Macrophages via microRNA-33-Mediated Attenuation of ATP-Binding Cassette Transporter A1 Expression by Statins. PLoS One. 2016 May 3;11(5):e0154672.
  305. Sheen YJ, Sheu WH*. Association between hypoglycemia and dementia in patients with type 2 diabetes. Diabetes Res Clin Pract. 2016 Jun;116:279-87.
  306. Zhao M, Cooney MT, Sheu WH, Zuo H, Grobbee DE, Graham IM. Simplifying the audit of risk factor recording and control: A report from an international study in 11 countries. Eur J Prev Cardiol. 2016 Jul;23(11):1202-10.
  307. Wang JS, Lee CL, Lee WJ, Lee WL, Liang KW, Sheu WH*. Statin treatment is associated with a negative correlation between NT-proBNP and insulin resistance in patients without history of heart failure. Clin Chim Acta. 2016 Aug 1;459:84-88.
  308. Hsu CL, Sheu WH*. Diabetes and shoulder disorders. J Diabetes Investig. 2016 Sep;7(5):649-51.
  309. Liu C, Kraja AT, Smith JA, Sheu WH, et al. Meta-analysis identifies common and rare variants influencing blood pressure and overlapping with metabolic trait loci. Nat Genet. 2016 Oct;48(10):1162-70.
  310. Ehret GB, Ferreira T, Chasman DI, Sheu WH, et al. The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals. Nat Genet. 2016 Oct;48(10):1171-1184.
  311. Lee IT, Wang JS, Fu CP, Lin SY, Sheu WH*. Relationship between body weight and the increment in serum brain-derived neurotrophic factor after oral glucose challenge in men with obesity and metabolic syndrome: A prospective study. Medicine (Baltimore). 2016 Oct;95(43):e5260.
  312. Inagaki N, Sheu WH, Crowe S, Bhandari A, Gong Y, Patel S. Efficacy and safety of linagliptin in type 2 diabetes patients with self-reported hepatic disorders: A retrospective pooled analysis of 17 randomized, double-blind, placebo-controlled clinical trials. J Diabetes Complications. 2016 Nov-Dec;30(8):1622-1630.
  313. Chiang SS, Lee CL, Liu HC, Li YF, Sheu WH, Lin SY. Physical activity and albuminuria were associated with painful diabetic polyneuropathy in type 2 diabetes in an ethnic Chinese population. Clin Chim Acta. 2016 Nov 1;462:55-59.
  314. Chang YC, Chiu YF, Sheu WH, Tsai SH, Chuang LM. Genome-wide linkage analysis and regional fine mapping identified variants in the RYR3 gene as a novel quantitative trait locus for circulating adiponectin in Chinese population. Medicine (Baltimore). 2016 Nov;95(44):e5174.
  315. Zubair N, Graff M, Sheu WH, North KE, Kooperberg C, Carty CL. Fine-mapping of lipid regions in global populations discovers ethnic-specific signals and refines previously identified lipid loci. Hum Mol Genet. 2016 Dec 15;25(24):5500-5512.
  316. Liang KW, Sheu WH, Lee WJ, Pan HC, Lee IT, Wang JS. Post-challenge insulin concentration is useful for differentiating between coronary artery disease and cardiac syndrome X in subjects without known diabetes mellitus. Diabetol Metab Syndr. 2017 Feb 8;9:10.
  317. Chen YW, Wang JS, Sheu WH, Song YM, Fu CP, Lee CL. Hemoglobin glycation index as a useful predictor of therapeutic responses to dipeptidyl peptidase-4 inhibitors in patients with type 2 diabetes. PLoS One. 2017 Feb 9;12(2):e0171753.
  318. Wang JS, Lee IT, Lee WJ, Tseng YH, Lin SY, Sheu WH*. Glycemic excursions are positively associated with HbA1c reduction from baseline after treatment with acarbose in patients with type 2 diabetes on metformin monotherapy. J Diabetes. 2017 Mar;9(3):248-255.
  319. Li M, Li Y, Weeks O, Jørgensen T, Sheu WH, et al. SOS2 and ACP1 Loci Identified through Large-Scale Exome Chip Analysis Regulate Kidney Development and Function. J Am Soc Nephrol. 2017 Mar;28(3):981-994.
  320. Sheen YJ, Sheu WH*. Response to the letter by Tomoyuki Kawada regarding the article entitled "Association between hypoglycemia and dementia in patients with type 2 diabetes". Diabetes Res Clin Pract. 2017 Mar;125:66-67.
  321. Lee IT, Wang JS, Lee WJ, Hsu CY, Sheu WH*. The synergistic effect of vascular cell adhesion molecule-1 and coronary artery disease on brain-derived neurotrophic factor. Clin Chim Acta. 2017 Mar;466:194-200.
  322. Liao WL, Lee WJ, Sheu WH, Yang CF, Wang CH, Tsai FJ. Pharmacogenetics of dipeptidyl peptidase 4 inhibitors in a Taiwanese population with type 2 diabetes. Oncotarget. 2017 Mar 14;8(11):18050-18058.
  323. Li C, Kim YK, Sheu WH, Tai ES, Kim BJ, Kelly TN. Genome-Wide Association Study Meta-Analysis of Long-Term Average Blood Pressure in East Asians. Circ Cardiovasc Genet. 2017 Apr;10(2):e001527.
  324. Spracklen CN, Chen P, Jia W, Sheu WH, et al. Association analyses of East Asian individuals and trans-ancestry analyses with European individuals reveal new loci associated with cholesterol and triglyceride levels. Hum Mol Genet. 2017 May 1;26(9):1770-1784.
  325. Chen CL, Yen DH, Lin CS, Sheu WH, Hsu CW. Glycated hemoglobin level is an independent predictor of major adverse cardiac events after nonfatal acute myocardial infarction in nondiabetic patients: A retrospective observational study. Medicine (Baltimore). 2017 May;96(18):e6743.
  326. Hsieh YM, Lee WJ, Sheu WH, Li YH, Lin SY, Lee IT. Inpatient screening for albuminuria and retinopathy to predict long-term mortality in type 2 diabetic patients: a retrospective cohort study. Diabetol Metab Syndr. 2017 May 3;9:29.
  327. Fernández-Rhodes L, Gong J, Sheu WH, Peters U, North KE. Trans-ethnic fine-mapping of genetic loci for body mass index in the diverse ancestral populations of the Population Architecture using Genomics and Epidemiology (PAGE) Study reveals evidence for multiple signals at established loci. Hum Genet. 2017 Jun;136(6):771-800.
  328. Sheu WH, Ji L, Lee WJ, Jabbar A, Han JH, Lew T. Efficacy and safety of premixed insulin analogs in Asian patients with type 2 diabetes: A systematic review. J Diabetes Investig. 2017 Jul;8(4):518-534.
  329. Howson JMM, Zhao W, Sheu WH, Butterworth AS, Saleheen D. Fifteen new risk loci for coronary artery disease highlight arterial-wall-specific mechanisms. Nat Genet. 2017 Jul;49(7):1113-1119.
  330. Dewey FE, Gusarova V, Sheu WH, Mellis SJ, Gromada J, Baras A. Genetic and Pharmacologic Inactivation of ANGPTL3 and Cardiovascular Disease. N Engl J Med. 2017 Jul 20;377(3):211-221.
  331. Sheu WH, Wang WC, Wu KD, Ting CT, Chen YI, Hsiung CA. CRP-level-associated polymorphism rs1205 within the CRP gene is associated with 2-hour glucose level: The SAPPHIRe study. Sci Rep. 2017 Aug 11;7(1):7987.
  332. Ballantyne CM, Shah S, Sheu WH, Briones IR, Mitchel YB. A Multiregional, Randomized Evaluation of the Lipid-Modifying Efficacy and Tolerability of Anacetrapib Added to Ongoing Statin Therapy in Patients With Hypercholesterolemia or Low High-Density Lipoprotein Cholesterol. Am J Cardiol. 2017 Aug 15;120(4):569-576.
  333. Lai DW, Lin KH, Sheu WH, Chung TJ, Liu SH, Sheu ML. TPL2 (Therapeutic Targeting Tumor Progression Locus-2)/ATF4 (Activating Transcription Factor-4)/SDF1α (Chemokine Stromal Cell-Derived Factor-α) Axis Suppresses Diabetic Retinopathy. Circ Res. 2017 Sep 1;121(6):e37-e52.
  334. Wang JS, Sheu WH, Lee WJ, Lee WL, Liang KW, Lin SJ. Associations of fibroblast growth factor 21 with cardiovascular risk and β-cell function in patients who had no history of diabetes. Clin Chim Acta. 2017 Sep;472:80-85.
  335. Lee IT, Wang JS, Fu CP, Chang CJ, Lee WJ, Lin SY, Sheu WH*. The synergistic effect of inflammation and metabolic syndrome on intraocular pressure: A cross-sectional study. Medicine (Baltimore). 2017 Sep;96(36):e7851.
  336. Wheeler E, Leong A, Sheu WH, et al. Impact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations: A transethnic genome-wide meta-analysis. PLoS Med. 2017 Sep 12;14(9):e1002383.
  337. Holman RR, Bethel MA ; EXSCEL Study Group(Sheu WH). Effects of Once-Weekly Exenatide on Cardiovascular Outcomes in Type 2 Diabetes. N Engl J Med. 2017 Sep 28;377(13):1228-1239.
  338. Zhao W, Rasheed A, Saleheen D(Sheu WH). Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease. Nat Genet. 2017 Oct;49(10):1450-1457.
  339. Liang KW, Sheu WH, Lee WJ, Lee WL, Fu CP, Wang JS. Differential expression of circulating vascular cell adhesion molecule-1 in subjects with coronary artery disease and cardiac syndrome X without known diabetes mellitus. Biomarkers. 2017 Dec;22(8):798-804.
  340. Sobrin L, Chong YH, Fan Q, Wong TY, Cheng CY, Sheu WH. Genetically Determined Plasma Lipid Levels and Risk of Diabetic Retinopathy: A Mendelian Randomization Study. Diabetes. 2017 Dec;66(12):3130-3141.
  341. Lu X, Peloso GM, Sheu WH, Sham PC, Gu D, Willer CJ. Exome chip meta-analysis identifies novel loci and East Asian-specific coding variants that contribute to lipid levels and coronary artery disease. Nat Genet. 2017 Dec;49(12):1722-1730.
  342. Jardine MJ, Mahaffey KW; CREDENCE study investigators(Sheu WH). The Canagliflozin and Renal Endpoints in Diabetes with Established Nephropathy Clinical Evaluation (CREDENCE) Study Rationale, Design, and Baseline Characteristics. Am J Nephrol. 2017 Dec 13;46(6):462-472.
  343. Gerstein HC, Colhoun HM, Sheu WH; REWIND Trial Investigators. Design and baseline characteristics of participants in the Researching cardiovascular Events with a Weekly INcretin in Diabetes (REWIND) trial on the cardiovascular effects of dulaglutide. Diabetes Obes Metab. 2018 Jan;20(1):42-49.
  344. Lee IT, Chen CH, Wang JS, Liang KW, Lin SY, Sheu WH*. The association between brain-derived neurotrophic factor and central pulse pressure after an oral glucose tolerance test. Clin Chim Acta. 2018 Jan;476:1-8.
  345. Turcot V, Lu Y, Highland HM, Sheu WH, et al. Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity. Nat Genet. 2018 Jan;50(1):26-41.
  346. Lee CL, Sheu WH, Lee IT, Lin SY, Liang WM, Wang JS, Li YF. Trajectories of fasting plasma glucose variability and mortality in type 2 diabetes. Diabetes Metab. 2018 Mar;44(2):121-128.
  347. Chiang CE, Lin SY, Lin TH, Yeh SJ, Sheu WH*, Lin JL. 2018 consensus of the Taiwan Society of Cardiology and the Diabetes Association of Republic of China (Taiwan) on the pharmacological management of patients with type 2 diabetes and cardiovascular diseases. J Chin Med Assoc. 2018 Mar;81(3):189-222.
  348. Sung YJ, Winkler TW; COGENT-Kidney Consortium, Sheu WH, et al. A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. Am J Hum Genet. 2018 Mar 1;102(3):375-400.
  349. Wang JS, Hung YJ, Lu YC, Lee TI, Hsiao YC, Sheu WH*. Difference between observed and predicted glycated hemoglobin at baseline and treatment response to vildagliptin-based dual oral therapy in patients with type 2 diabetes. Diabetes Res Clin Pract. 2018 Apr;138:119-127.
  350. Mahajan A, Wessel J, Lin KH, Sheu WH, et al. Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes. Nat Genet. 2018 Apr;50(4):559-571.
  351. Lee IT, Sheu WH, Lee WJ, Chen DY. Serum brain-derived neurotrophic factor predicting reduction in pulse pressure after a one-hour rest in nurses working night shifts. Sci Rep. 2018 Apr 3;8(1):5485.
  352. Emdin CA, Khera AV, Sheu WH, Saleheen D, Gabriel S, Kathiresan S. Analysis of predicted loss-of-function variants in UK Biobank identifies variants protective for disease. Nat Commun. 2018 Apr 24;9(1):1613.
  353. Turcot V, Lu Y, Easton DF, Sheu WH, et al. Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity. Nat Genet. 2018 May;50(5):765-766.
  354. Turcot V, Lu Y, Easton DF, Sheu WH, et al. Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity. Nat Genet. 2018 May;50(5):766-767.
  355. Li YH, Sheu WH, Lee WJ, Wang J-, Fu CP, Liang KW, Lee IT. Synergistic effect of renalase and chronic kidney disease on endothelin-1 in patients with coronary artery disease ‒ a cross-sectional study. Sci Rep. 2018 May 9;8(1):7378.
  356. Teng CJ, Chang KH, Tsai IJ, Hwang WL, Hsu CY, Sheu WH*. Impact of Anthracyclines on Diabetes Mellitus Development in B-Cell Lymphoma Patients: A Nationwide Population-based Study. Clin Drug Investig. 2018 Jul;38(7):603-610.
  357. Zekavat SM, Ruotsalainen S; NHLBI TOPMed Lipids Working Group(Sheu WH). Deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestries. Nat Commun. 2018 Jul 4;9(1):2606.
  358. Chang TJ, Wang WC, Sheu WH, Chuang LM; SAPPHIRe Study Group. Genetic variation of SORBS1 gene is associated with glucose homeostasis and age at onset of diabetes: A SAPPHIRe Cohort Study. Sci Rep. 2018 Jul 12;8(1):10574.
  359. Li YH, Sheu WH, Lee IT. Effects of retinopathy and chronic kidney disease on long-term mortality in type 2 diabetic inpatients with normal urinary albumin or protein: a retrospective cohort study. BMJ Open. 2018 Jul 25;8(7):e021655.
  360. Li YH, Sheu WH, Lee WJ, Lee WL, Liang KW, Wang JS. Testing for HbA1c, in addition to the oral glucose tolerance test, in screening for abnormal glucose regulation helps to reveal patients with early β-cell function impairment. Clin Chem Lab Med. 2018 Jul 26;56(8):1345-1352.
  361. Chang YL, Sheu WH, Lin SY, Liou WS. Good glycaemic control is associated with a better prognosis in breast cancer patients with type 2 diabetes mellitus. Clin Exp Med. 2018 Aug;18(3):383-390.
  362. Wang JS, Sheu WH, Lee WJ, Lee IT, Lin SY, Lee WL, Liang KW, Lin SJ. Levels of serum high mobility group box 1 were independently associated with cardiovascular risk in patients undergoing coronary angiography. Clin Chim Acta. 2018 Aug;483:130-134.
  363. Fu CP, Sheu WH, Lee WL, Lee WJ, Wang JS, Lin SY, Lee IT. Two-hour post-challenge hyperglycemia, but not fasting plasma glucose, associated with severity of coronary artery disease in patients with angina. PLoS One. 2018 Aug 15;13(8):e0202280.
  364. Natarajan P, Peloso GM; NHLBI TOPMed Lipids Working Group(Sheu WH). Deep-coverage whole genome sequences and blood lipids among 16,324 individuals. Nat Commun. 2018 Aug 23;9(1):3391.
  365. Zekavat SM, Ruotsalainen S; NHLBI TOPMed Lipids Working Group(Sheu WH). Publisher Correction: Deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestries. Nat Commun. 2018 Aug 23;9(1):3493.
  366. Jabbar A, Mohamed WMIBW, Sheu WH, Babineaux SM. Patterns and trends in insulin initiation and intensification among patients with type 2 diabetes mellitus in the Western Pacific region. Curr Med Res Opin. 2018 Sep;34(9):1653-1662.
  367. Liang KW, Lee WJ, Lee IT, Lin SY, Wang JS, Lee WL, Sheu WH*. Regaining body weight after weight reduction further increases pulse wave velocity in obese men with metabolic syndrome. Medicine (Baltimore). 2018 Oct;97(40):e12730.
  368. Hsu CL, Sheu WH*. History of gestational diabetes and future cardiovascular disease: What have we learned? J Diabetes Investig. 2018 Nov;9(6):1258-1260.
  369. Wang CY, Tu ST, Sheu WH, Chuang LM, Wu MS, Yu CJ. National survey of ABC (A1C, blood pressure, cholesterol) of Diabetes Health Promotion Institutes in Taiwan: 2002-2018. J Formos Med Assoc. 2018 Nov;117(11):952-954.
  370. Lee IT, Sheu WH. Serum Renalase Levels Are Predicted by Brain-Derived Neurotrophic Factor and Associated with Cardiovascular Events and Mortality after Percutaneous Coronary Intervention. J Clin Med. 2018 Nov 12;7(11):437.
  371. Wang JS, Lee WJ, Lee IT, Liang KW, Lin SJ, Sheu WH*. Negative association between serum aryl hydrocarbon receptor concentrations and β-cell function in patients with no history of diabetes undergoing coronary angiography. J Diabetes. 2018 Dec;10(12):958-964.
  372. Sheen YJ, Li TC, Lin JL, Tsai WC, Kao CD, Bau CT, Sheu WH. Association between thermal threshold abnormalities and peripheral artery disease in patients with type 2 diabetes. Medicine (Baltimore). 2018 Dec;97(51):e13803.
  373. Kraja AT, Liu C, Fetterman JL, Stergiakouli E, Sheu WH, et al. Associations of Mitochondrial and Nuclear Mitochondrial Variants and Genes with Seven Metabolic Traits. Am J Hum Genet. 2019 Jan 3;104(1):112-138.
  374. Pollack S, Igo RP Jr, Jensen RA, Sheu WH, Price AL, Sobrin L. Multiethnic Genome-Wide Association Study of Diabetic Retinopathy Using Liability Threshold Modeling of Duration of Diabetes and Glycemic Control. Diabetes. 2019 Feb;68(2):441-456.
  375. Wang JS, Lee WJ, Lee IT, Lin SY, Lee WL, Liang KW, Sheu WH*. Association Between Serum Adipsin Levels and Insulin Resistance in Subjects With Various Degrees of Glucose Intolerance. J Endocr Soc. 2018 Dec 21;3(2):403-410.
  376. Bain SC, Mosenzon O, Sheu WH, Thomsen M, Husain M. Cardiovascular safety of oral semaglutide in patients with type 2 diabetes: Rationale, design and patient baseline characteristics for the PIONEER 6 trial. Diabetes Obes Metab. 2019 Mar;21(3):499-508.
  377. Tien KJ, Hung YJ, Chen JF, Tu ST, Wang CH, Sheu WH*. Basal insulin therapy: Unmet medical needs in Asia and the new insulin glargine in diabetes treatment. J Diabetes Investig. 2019 May;10(3):560-570.
  378. Liao CY, Wu MF, Poon SK, Wu CL, Sheu WH, Liou WS. Improving medication safety by cloud technology: Progression and value-added applications in Taiwan. Int J Med Inform. 2019 Jun;126:65-71.
  379. Perkovic V, Jardine MJ; CREDENCE Trial Investigators(Sheu WH). Canagliflozin and Renal Outcomes in Type 2 Diabetes and Nephropathy. N Engl J Med. 2019 Jun 13;380(24):2295-2306.
  380. Turcot V, Lu Y, Highland HM, Easton DF, Sheu WH, et al. Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity. Nat Genet. 2019 Jul;51(7):1191-1192.
  381. Gerstein HC, Colhoun HM, Sheu WH; REWIND Investigators. Dulaglutide and renal outcomes in type 2 diabetes: an exploratory analysis of the REWIND randomised, placebo-controlled trial. Lancet. 2019 Jul 13;394(10193):131-138.
  382. Gerstein HC, Colhoun HM, Sheu WH; REWIND Investigators. Dulaglutide and cardiovascular outcomes in type 2 diabetes (REWIND): a double-blind, randomised placebo-controlled trial. Lancet. 2019 Jul 13;394(10193):121-130.
  383. Sung YJ, de Las Fuentes L, Sheu WH, de Silva HJ, et al. A multi-ancestry genome-wide study incorporating gene-smoking interactions identifies multiple new loci for pulse pressure and mean arterial pressure. Hum Mol Genet. 2019 Aug 1;28(15):2615-2633.
  384. Husain M, Birkenfeld AL; PIONEER 6 Investigators(Sheu WH). Oral Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes. N Engl J Med. 2019 Aug 29;381(9):841-851.
  385. Clark DW, Okada Y, Chen G, Sheu WH, et al. Associations of autozygosity with a broad range of human phenotypes. Nat Commun. 2019 Oct 31;10(1):4957.
  386. Deerochanawong C, Chan SP, Sheu WH, Mithal A, Linong J. Use of sodium-glucose co-transporter-2 inhibitors in patients with type 2 diabetes mellitus and multiple cardiovascular risk factors: An Asian perspective and expert recommendations. Diabetes Obes Metab. 2019 Nov;21(11):2354-2367.
  387. Sheen YJ, Hsu CC, Jiang YD, Huang CN, Liu JS, Sheu WH*. Trends in prevalence and incidence of diabetes mellitus from 2005 to 2014 in Taiwan. J Formos Med Assoc. 2019 Nov;118 Suppl 2:S66-S73.
  388. Hsu CC, Tu ST, Sheu WH*. 2019 Diabetes Atlas: Achievements and challenges in diabetes care in Taiwan. J Formos Med Assoc. 2019 Nov;118 Suppl 2:S130-S134.
  389. Lee IT, Hsu CC, Sheu WH, Su SL, Wu YL, Lin SY. Pay-for-performance for shared care of diabetes in Taiwan. J Formos Med Assoc. 2019 Nov;118 Suppl 2:S122-S129.
  390. Wang CY, Wu YL, Sheu WH, Tu ST, Hsu CC, Tai TY. Accountability and utilization of diabetes care from 2005 to 2014 in Taiwan. J Formos Med Assoc. 2019 Nov;118 Suppl 2:S111-S121.
  391. Kachroo P, Hecker J; TOPMed Group(Sheu WH). Whole Genome Sequencing Identifies CRISPLD2 as a Lung Function Gene in Children With Asthma. Chest. 2019 Dec;156(6):1068-1079.
  392. Sinclair AJ, Dunning T; an International Group of Experts(Sheu WH). Clinical guidelines for type 1 diabetes mellitus with an emphasis on older adults: an Executive Summary. Diabet Med. 2020 Jan;37(1):53-70.
  393. Liao CC, Sheu WH, Lin SY, Lee WJ, Lee IT. The Relationship Between Abdominal Body Composition and Metabolic Syndrome After a Weight Reduction Program in Adult Men with Obesity. Diabetes Metab Syndr Obes. 2020 Jan 6;13:1-8.
  394. Shieh GJ, Wu SL, Tsai CF, Chang TH, Lui PW, Yao Y, Sheu WH*. A Strategic Imperative for Promoting Hospital Branding: Analysis of Outcome Indicators. Interact J Med Res. 2020 Jan 22;9(1):e14546.
  395. Sheen YJ, Huang CC, Huang SC, Lee IT, Lin SY, Sheu WH*. IMPLEMENTATION OF AN ELECTRONIC DASHBOARD WITH A REMOTE MANAGEMENT SYSTEM TO IMPROVE GLYCEMIC MANAGEMENT AMONG HOSPITALIZED ADULTS. Endocr Pract. 2020 Feb;26(2):179-191.
  396. Hsieh YC, Liao YC, Li CH, Wang JS, Wu TJ, Sheu WH. Hypoglycaemic episodes increase the risk of ventricular arrhythmia and sudden cardiac arrest in patients with type 2 diabetes-A nationwide cohort study. Diabetes Metab Res Rev. 2020 Feb;36(2):e3226.
  397. Gerstein HC, Hart R, Sheu WH, Temelkova-Kurktschiev T. The effect of dulaglutide on stroke: an exploratory analysis of the REWIND trial. Lancet Diabetes Endocrinol. 2020 Feb;8(2):106-114.
  398. Sheu WH, Chan SP, Matawaran BJ, Linong J, Luk A, Yoon KH. Use of SGLT-2 Inhibitors in Patients with Type 2 Diabetes Mellitus and Abdominal Obesity: An Asian Perspective and Expert Recommendations. Diabetes Metab J. 2020 Feb;44(1):11-32.
  399. Kessler MD, Loesch DP; TOPMed Group(Sheu WH). De novo mutations across 1,465 diverse genomes reveal mutational insights and reductions in the Amish founder population. Proc Natl Acad Sci U S A. 2020 Feb 4;117(5):2560-2569.
  400. Liang KW, Lee WJ, Lee IT, Lee WL, Wang JS, Wu JP, Sheu WH. Subjects with microvascular angina have longer GT repeats polymorphism in the haem oxygenase-1 gene promoter. Biomarkers. 2020 Mar;25(2):144-148.
  401. Li YH, Sheu WH, Lee IT. Influence of Diabetic Retinopathy on the Relationship Between Body Mass Index and Mortality in Patients with Poorly Controlled Type 2 Diabetes. Diabetes Metab Syndr Obes. 2020 Mar 24;13:907-914.
  402. Kong APS, Lew T, Sheu WH; JADE Collaborative Study Group. Real-world data reveal unmet clinical needs in insulin treatment in Asian people with type 2 diabetes: the Joint Asia Diabetes Evaluation (JADE) Register. Diabetes Obes Metab. 2020 Apr;22(4):669-679.
  403. Zekavat SM, Ruotsalainen S; TOPMed Group (Sheu WH). Publisher Correction: Deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestries. Nat Commun. 2020 Apr 1;11(1):1715.
  404. Lo YC, Lin KH, Bair H, Sheu WH, Chang CS, Shen YC, Hung CL. Epiretinal Membrane Detection at the Ophthalmologist Level using Deep Learning of Optical Coherence Tomography. Sci Rep. 2020 May 21;10(1):8424.
  405. Wang JS, Chen H, Tang F, Sheu WH*. Associations of fear of hypoglycemia with second-line use of insulin secretagogues or insulin and subsequent glycemic control in patients with type 2 diabetes: An analysis using data from the DISCOVER study. Int J Clin Pract. 2020 Jun;74(6):e13485.
  406. Pollack S, Igo RP Jr, Sheu WH, Iyengar SK, Price AL, Sobrin L. Erratum. Multiethnic Genome-Wide Association Study of Diabetic Retinopathy Using Liability Threshold Modeling of Duration of Diabetes and Glycemic Control. Diabetes 2019;68:441-456.Diabetes. 2020 Jun;69(6):1306.
  407. Spracklen CN, Horikoshi M, Sheu WH, Kato N, Park KS, et al. Identification of type 2 diabetes loci in 433,540 East Asian individuals. Nature. 2020 Jun;582(7811):240-245.
  408. Cukierman-Yaffe T, Gerstein HC, Sheu WH, Temelkova-Kurktschiev T. Effect of dulaglutide on cognitive impairment in type 2 diabetes: an exploratory analysis of the REWIND trial. Lancet Neurol. 2020 Jul;19(7):582-590.
  409. Lee IT, Li YH, Sheu WH*. Brain-Derived Neurotrophic Factor during Oral Glucose Tolerance Test Predicts Cardiovascular Outcomes. Int J Mol Sci. 2020 Jul 15;21(14):5008.
  410. Wu CL, Liou CH, Liu SA, Sheu WH, Tsai SF. Health Literacy Varies According to Different Background Disease Natures and Characteristics of Participants for Patient Support Groups. Int J Environ Res Public Health. 2020 Aug 7;17(16):5702.
  411. Sheu WH*. Lowering the risk of gout: Another benefits from the use of sodium-glucose cotransporter 2 inhibitors. J Diabetes Investig. 2020 Sep;11(5):1115-1116.
  412. Li X, Li Z, Zhou H; TOPMed Group (Sheu WH). Dynamic incorporation of multiple in silico functional annotations empowers rare variant association analysis of large whole-genome sequencing studies at scale. Nat Genet. 2020 Sep;52(9):969-983.
  413. Wu CL, Liou CH, Liu SA, Chen CH, Sheu WH, Chou IJ, Tsai SF. Quality Improvement Initiatives in Reforming Patient Support Groups-Three-Year Outcomes. Int J Environ Res Public Health. 2020 Sep 30;17(19):7155.
  414. Bick AG, Weinstock JS, Sheu WH,et al. Inherited causes of clonal haematopoiesis in 97,691 whole genomes. Nature. 2020 Oct;586(7831):763-768.
  415. Cannon CP, Pratley R, Dagogo-Jack S; VERTIS CV Investigators(Sheu WH). Cardiovascular Outcomes with Ertugliflozin in Type 2 Diabetes. N Engl J Med. 2020 Oct 8;383(15):1425-1435.
  416. Li YH, Sheu WH, Lee IT. Use of the ankle-brachial index combined with the percentage of mean arterial pressure at the ankle to improve prediction of all-cause mortality in type 2 diabetes mellitus: an observational study. Cardiovasc Diabetol. 2020 Oct 9;19(1):173.
  417. Sheen YJ, Kung PT, Sheu WH, Kuo WY, Tsai WC. Impact of Liver Cirrhosis on Incidence of Dialysis Among Patients with Type 2 Diabetes. Diabetes Ther. 2020 Nov;11(11):2611-2628.
  418. Wu CL, Liou CH, Liu SA, Sheu WH, Tsai SF. Mandarin multidimensional health literacy questionnaire for patient supporting groups: A quality improvement article. Medicine (Baltimore). 2020 Nov 6;99(45):e23182.
  419. Chu WM, Shieh GJ, Wu SL, Sheu WH*. Use of Facebook by Academic Medical Centers in Taiwan During the COVID-19 Pandemic: Observational Study. J Med Internet Res. 2020 Nov 20;22(11):e21501.
  420. Dagenais GR, Rydén L, Sheu WH, Riddle MC, Gerstein HC. Total cardiovascular or fatal events in people with type 2 diabetes and cardiovascular risk factors treated with dulaglutide in the REWIND trail: a post hoc analysis. Cardiovasc Diabetol. 2020 Nov 25;19(1):199.
  421. Tang NH, Tsai SF, Liou JH, Lai YH, Liu SA, Sheu WH, Wu CL. The Association between the Participation of Quality Control Circle and Patient Safety Culture. Int J Environ Res Public Health. 2020 Nov 29;17(23):8872.
  422. Surendran P, Feofanova EV, Braund PS, Sheu WH, et al. Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals. Nat Genet. 2020 Dec;52(12):1314-1332.
  423. Chu EP, Cho CH, Lee WJ, Chen RY, Sheu WH, Shen CN. Generation of three induced pluripotent stem cell lines from type 2 diabetic patients with ocular complications. Stem Cell Res. 2020 Dec;49:102109.
  424. Li YH, Tseng WK, Yin WH, Sheu WH, Yeh HI. Prognostic effect of high-density lipoprotein cholesterol level in patients with atherosclerotic cardiovascular disease under statin treatment. Sci Rep. 2020 Dec 14;10(1):21835.
  425. Nielsen JB, Rom O, Cucca F, Holmen OL, Sheu WH, et al. Loss-of-function genomic variants highlight potential therapeutic targets for cardiovascular disease. Nat Commun. 2020 Dec 18;11(1):6417.
  426. Ji L, Chan JCN, Yu M, Wang CY, Paldánius PM, Sheu WH*. Early combination versus initial metformin monotherapy in the management of newly diagnosed type 2 diabetes: An East Asian perspective. Diabetes Obes Metab. 2021 Jan;23(1):3-17.
  427. Sheu WH, Lin KH, Wang JS, Lee MR, Liu SH, Sheu ML. Therapeutic Potential of Tpl2 (Tumor Progression Locus 2) Inhibition on Diabetic Vasculopathy Through the Blockage of the Inflammasome Complex. Arterioscler Thromb Vasc Biol. 2021 Jan;41(1):e46-e62.
  428. Lin BM, Grinde KE, Brody JA, Sheu WH, Franceschini N. Whole genome sequence analyses of eGFR in 23,732 people representing multiple ancestries in the NHLBI trans-omics for precision medicine (TOPMed) consortium. EBioMedicine. 2021 Jan;63:103157.
  429. Khoo CM, Deerochanawong C, Sheu WH, Man NH, Pollock C. Use of sodium-glucose co-transporter-2 inhibitors in Asian patients with type 2 diabetes and kidney disease: An Asian perspective and expert recommendations. Diabetes Obes Metab. 2021 Feb;23(2):299-317.
  430. Fahed AC, Aragam KG, Sheu WH, Kathiresan S, Khera AV. Transethnic Transferability of a Genome-Wide Polygenic Score for Coronary Artery Disease. Circ Genom Precis Med. 2021 Feb;14(1):e003092.
  431. Taliun D, Harris DN, Kessler MD, Liu C, Loos RJF, Sheu WH, et al. Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program. Nature. 2021 Feb;590(7845):290-299.
  432. Reiner AP, Raffield LM; TOPMed Group (Sheu WH). Effect of Sickle Cell Trait and APOL1 Genotype on the Association of Soluble uPAR with Kidney Function Measures in Black Americans. Clin J Am Soc Nephrol. 2021 Feb 8;16(2):287-289.
  433. Bick AG, Weinstock JS, Nandakumar SK, Sheu WH, et al. Author Correction: Inherited causes of clonal haematopoiesis in 97,691 whole genomes. Nature. 2021 Mar;591(7851):E27.
  434. Li YH, Sheu WH, Chou CC, Wang CY, Wu CL, Lee IT. The Clinical Influence after Implementation of Convolutional Neural Network-Based Software for Diabetic Retinopathy Detection in the Primary Care Setting. Life (Basel). 2021 Mar 5;11(3):200.
  435. Lim LL, Lau ESH, Sheu WH, Chan JCN; Asia-Pacific JADE Study Group. Effects of a Technology-Assisted Integrated Diabetes Care Program on Cardiometabolic Risk Factors Among Patients With Type 2 Diabetes in the Asia-Pacific Region: The JADE Program Randomized Clinical Trial. JAMA Netw Open. 2021 Apr 1;4(4):e217557.
  436. Natarajan P, Pampana A, Willer C, Sheu WH, et al. Chromosome Xq23 is associated with lower atherogenic lipid concentrations and favorable cardiometabolic indices. Nat Commun. 2021 Apr 12;12(1):2182.
  437. Kasela S, Ortega VE; TOPMed Group(Sheu WH). Genetic and non-genetic factors affecting the expression of COVID-19-relevant genes in the large airway epithelium. Genome Med. 2021 Apr 21;13(1):66.
  438. Wu CL, Kuo CT, Shih SJ, Huang MD, Sheu WH, Liu SA. Implementation of an Electronic National Early Warning System to Decrease Clinical Deterioration in Hospitalized Patients at a Tertiary Medical Center. Int J Environ Res Public Health. 2021 Apr 25;18(9):4550.
  439. Liang KW, Lee WJ, Lee WL, Wu JP, Lee IT, Wang JS, Sheu WH. Subjects with coronary artery disease and reduced ejection fraction have longer (GT)(n) repeats in the heme-oxygenase 1 gene promoter. Heart Vessels. 2021 May;36(5):615-620.
  440. Surendran P, Feofanova EV, Burgess S, Sheu WH, et al. Publisher Correction: Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals. Nat Genet. 2021 May;53(5):762.
  441. Zhou Z, Jardine MJ, Li Q, Sheu WH,CREDENCE Trial Investigators*. Effect of SGLT2 Inhibitors on Stroke and Atrial Fibrillation in Diabetic Kidney Disease: Results From the CREDENCE Trial and Meta-Analysis. Stroke. 2021 May;52(5):1545-1556.
  442. Lin TH, Lee WL, Lee WJ, Sheu WH, Liao YC, Liang KW. Dyslipidemia, Not Inflammatory Markers or Adipokines, Contributes Significantly to a Higher SYNTAX Score in Stable Coronary Artery Disease (from the Taichung CAD Study). Acta Cardiol Sin. 2021 May;37(3):232-238.
  443. Wang JS, Lee IT, Lee WJ, Lin SY, Lee WL, Liang KW, Sheu WH. Postchallenge glucose increment was associated with hemoglobin glycation index in subjects with no history of diabetes. J Investig Med. 2021 Jun;69(5):1044-1049.
  444. Sofer T, Zheng X; TOPMed Group(Sheu WH). Variant-specific inflation factors for assessing population stratification at the phenotypic variance level. Nat Commun. 2021 Jun 9;12(1):3506.
  445. Li YH, Sheu WH, Yeh WC, Chang YC, Lee IT. Predicting Long-Term Mortality in Patients with Angina across the Spectrum of Dysglycemia: A Machine Learning Approach. Diagnostics (Basel). 2021 Jun 9;11(6):1060.
  446. Keramati AR, Chen MH, Mathias RA, Sheu WH. Genome sequencing unveils a regulatory landscape of platelet reactivity. Nat Commun. 2021 Jun 15;12(1):3626.
  447. Marx N, Ryden L, Brosius F, Sheu WH, Standl E, Schnell O. Towards living guidelines on cardiorenal outcomes in diabetes: A pilot project of the Taskforce of the Guideline Workshop 2020. Diabetes Res Clin Pract. 2021 Jul;177:108870.
  448. Ferrannini G, Gerstein H, Colhoun HM, Sheu WH, Rydén L. Similar cardiovascular outcomes in patients with diabetes and established or high risk for coronary vascular disease treated with dulaglutide with and without baseline metformin. Eur Heart J. 2021 Jul 8;42(26):2565-2573.
  449. Bajaj HS, Gerstein HC, Rao-Melacini P, Sheu WH, Xavier D. Erectile function in men with type 2 diabetes treated with dulaglutide: an exploratory analysis of the REWIND placebo-controlled randomised trial. Lancet Diabetes Endocrinol. 2021 Aug;9(8):484-490.
  450. Wang JS, Lee IT, Lee WJ, Tu ST, Lin SY, Sheu WH. The dawn phenomenon in type 2 diabetes: its association with glucose excursions and changes after oral glucose-lowering drugs. Ther Adv Chronic Dis. 2021 Aug 10;12:20406223211033674.
  451. Cade BE, Lee J, Sofer T, Wang H; TOPMed Group(Sheu WH). Whole-genome association analyses of sleep-disordered breathing phenotypes in the NHLBI TOPMed program. Genome Med. 2021 Aug 26;13(1):136.
  452. Wang JS, Lo SH, Yeh YP, Huang CN, Hsieh CH, Sheu WH*. Distinct associations of self-monitoring of blood glucose with glycemic control and hypoglycemia between groups of recently diagnosed and long-term follow-up type 2 diabetes: The Taiwan Diabetes Registry. Int J Clin Pract. 2021 Sep;75(9):e14410.
  453. Cherney DZI, Cosentino F; VERTIS CV Investigators(Sheu WH). Ertugliflozin and Slope of Chronic eGFR: Prespecified Analyses from the Randomized VERTIS CV Trial. Clin J Am Soc Nephrol. 2021 Sep;16(9):1345-1354.
  454. Lee WJ, Chuang HN, Chen YM, Sheu WH, Lee WL, Hsiao TH. Familial Hypercholesterolemia Genetic Variations and Long-Term Cardiovascular Outcomes in Patients with Hypercholesterolemia Who Underwent Coronary Angiography. Genes (Basel). 2021 Sep 14;12(9):1413.
  455. Luo Y, Kanai M, Choi W; TOPMed Group (Sheu WH). A high-resolution HLA reference panel capturing global population diversity enables multi-ancestry fine-mapping in HIV host response. Nat Genet. 2021 Oct;53(10):1504-1516.
  456. Liang KW, Lee WJ, Lee WL, Wu JP, Sheu WH. Shorter (GT)(n) repeats in the haem-oxygenase 1 gene promoter are associated with better mid-term survival in subjects with coronary artery disease and abnormal ejection fraction. Biomarkers. 2021 Dec;26(8):732-736.
  457. Luo Y, Kanai M; TOPMed Group (Sheu WH). Author Correction: A high-resolution HLA reference panel capturing global population diversity enables multi-ancestry fine-mapping in HIV host response. Nat Genet. 2021 Dec;53(12):1722.
  458. Tzeng TY, Hsu CA, Yang YY, Hou MC, Chen CH, Sheu WH. The Impact of COVID-19 Pandemic on the Learning Outcomes of Medical Students in Taiwan: A Two-Year Prospective Cohort Study of OSCE Performance. Int J Environ Res Public Health. 2021 Dec 25;19(1):208.
  459. Lien AS, Chiu SY,Yang YY, Sheu WH, Chen HH, Gau BS. Community-based multiple screening for metabolic syndrome by innovative theory: A longitudinal study. Public Health Nurs. 2022 Jan;39(1):303-312.
  460. Wu JW, Cheng HM, Huang SS, Yang YY, Hou MC, Sheu WH. Comparison of OSCE performance between 6- and 7-year medical school curricula in Taiwan. BMC Med Educ. 2022 Jan 4;22(1):15.
  461. Chiang DH, Chen CT, Yang YY, Hou MC, Sheu WH. Enhancing the learning and transfer of preprocedural communication skills during clerkship using audio-visual material: a prospective case-controlled study over 2 years. BMJ Open. 2022 Jan 5;12(1):e055953.
  462. Taub MA, Conomos MP, Redline S, Raby BA, Sheu WH , et al. Genetic determinants of telomere length from 109,122 ancestrally diverse whole-genome sequences in TOPMed. Cell Genom. 2022 Jan 12;2(1):100084.
  463. Sheen YJ, Sheu WH, Wang HC, Chen JP, Sun YH, Chen HM. Assessment of diabetic small-fiber neuropathy by using short-wave infrared hyperspectral imaging. J Biophotonics. 2022 Feb;15(2):e202100220.
  464. Katz DH, Tahir UA; TOPMed Group (Sheu WH). Whole Genome Sequence Analysis of the Plasma Proteome in Black Adults Provides Novel Insights Into Cardiovascular Disease. Circulation. 2022 Feb;145(5):357-370.
  465. He KY, Kelly TN, Wang H; TOPMed Group (Sheu WH). Rare coding variants in RCN3 are associated with blood pressure. BMC Genomics. 2022 Feb 19;23(1):148.
  466. Lin CC, Wu MF, Chang YL, Sheu WH, Liou WS. Glycemic control was associated with nonprostate cancer and overall mortalities in diabetic patients with prostate cancer. J Chin Med Assoc. 2022 Mar 1;85(3):331-340.
  467. Wainschtein P, Jain D; TOPMed Group (Sheu WH). Assessing the contribution of rare variants to complex trait heritability from whole-genome sequence data. Nat Genet. 2022 Mar;54(3):263-273.
  468. Raubenheimer PJ, Cushman WC, Sheu WH, C Gerstein H. Dulaglutide and incident atrial fibrillation or flutter in patients with type 2 diabetes: A post hoc analysis from the REWIND randomized trial. Diabetes Obes Metab. 2022 Apr;24(4):704-712.
  469. Sheu WH, Seino Y, Tan EC, Kyaw MH; EMPRISE East Asia study group. Healthcare resource utilization in patients treated with empagliflozin in East Asia. J Diabetes Investig. 2022 May;13(5):810-821.
  470. Mahajan A, Spracklen CN, Zhang W, Sheu WH, et al. Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation. Nat Genet. 2022 May;54(5):560-572.
  471. Battelino T, Brosius F, Sheu WH, Standl E, Parkin CG, Schnell O. Guideline Development for Medical Device Technology: Issues for Consideration. J Diabetes Sci Technol. 2022 May 7:19322968221093355.
  472. Wu TH, Lee IT, Ho LT, Sheu WH, Hwu CM. Combined Lipid Goal Attainment in Patients with Type 2 Diabetes and Dyslipidemia: A Head-to-Head Comparative Trial of Statins. J Chin Med Assoc. 2022 Jun 20.
  473. Hsu CY, Sheu WH, Lee IT. Brain-Derived Neurotrophic Factor Reduces Long-Term Mortality in Patients With Coronary Artery Disease and Chronic Kidney Disease. Front Cardiovasc Med. 2022 Jun 21;9:881441.
  474. Li HY, Sheu WH*. Updates for hyperglycemia in pregnancy: The ongoing journey for maternal-neonatal health. J Diabetes Investig. 2022 Jul 6.
  475. Cukierman-Yaffe T, Gerstein HC, Sheu WH, Temelkova-Kurktschiev T. Novel Indices of Cognitive Impairment and Incident Cardiovascular Outcomes in the REWIND Trial. J Clin Endocrinol Metab. 2022 Jul 14;107(8):e3448-e3454.
  476. Cheung JTK, Lau E, Sheu WH, Lim LL, Chan JCN. Combined associations of family history and self-management with age at diagnosis and cardiometabolic risk in 86,931 patients with type 2 diabetes: Joint Asia Diabetes Evaluation (JADE) Register from 11 countries. BMC Med. 2022 Jul 14;20(1):249.
  477. Chen WL, Sheu WH, Li YH, Liang KW, Lee WL, Lee IT. Newly diagnosed diabetes based on an oral glucose tolerance test predicts cardiovascular outcomes in patients with coronary artery disease: An observational study. Medicine (Baltimore). 2022 Jul 15;101(28):e29557.
  478. Wang CY, Huang KC, Lu CW, Chu CH, Huang CN, Chen HS, Lee IT, Chen JF, Chen CC, Chen CS, Hsieh CH, Tien KJ, Chien HY, Huang YY, Hsu JP, Shane GT, Chang AC, Wu YC, Sheu WH*. A randomized controlled trial of R-form verapamil added to ongoing metformin therapy in patients with type 2 diabetes. J Clin Endocrinol Metab. 2022 Aug 2:dgac436. doi: 10.1210/clinem/dgac436. Epub ahead of print. PMID: 35917580
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